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Autoimmunity Volume 42, 2009 - Issue 5
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Original

Abnormal distribution of dendritic cells in (NZW × BXSB)F1 mice

Yoko Tokuyama First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-City, Osaka, 570-8506, Japan
,
Yasushi Adachi First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-City, Osaka, 570-8506, Japan
,
Keizo Minamino Department of Ophthalmology, Kansai Medical University, Moriguchi-City, Osaka, 570-8506, Japan
,
Hiroshi Shintaku Faculty of Medicine, Kansai Medical University, Moriguchi-City, Osaka, 570-8506, Japan
,
Mitsuhiko Okigaki Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kamigyo-ku, Kyoto, 602-0857, Japan
,
Kumi Hayashi First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-City, Osaka, 570-8506, Japan
,
Aiko Kitajima First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-City, Osaka, 570-8506, Japan
,
Takashi Takaki First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-City, Osaka, 570-8506, Japan
,
Naoko Koike First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-City, Osaka, 570-8506, Japan; Department of Ophthalmology, Kansai Medical University, Moriguchi-City, Osaka, 570-8506, Japan
,
Chieko Shima First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-City, Osaka, 570-8506, Japan; Department of Ophthalmology, Kansai Medical University, Moriguchi-City, Osaka, 570-8506, Japan
,
Yuichiro Imai First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-City, Osaka, 570-8506, Japan
,
Ming Shi First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-City, Osaka, 570-8506, Japan
,
Seiji Yanai First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-City, Osaka, 570-8506, Japan
&
Susumu Ikehara First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-City, Osaka, 570-8506, JapanCorrespondence[email protected]
 show all
Pages 399-405 | Received 02 Feb 2009, Accepted 08 Apr 2009, Published online: 13 Aug 2009
 
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Abstract

(NZW × BXSB)F1 mice (W/BF1 mice) have been reported to develop autoimmune diseases with aging. We have also reported that the number of dendritic cells (DCs) increases in the various organs, and that the B-cell response to LPS or interleukin-4 plus anti-μ increase with aging in W/BF1 mice. In the present experiment, we show that many DCs exist not only in the T-cell area but also in the B-cell area and the sinus in the spleen of aged W/BF1 mice, and that the coculturing of DCs from aged W/BF1 mice and B cells from disease-free young W/BF1 mice produces much more IgG and IgM than normal mice. These results suggest that an abnormal distribution of DCs and the interaction of DCs and B cells induce the hyperproduction of immunoglobulin in aged W/BF1 mice.

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