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Autoimmunity Volume 53, 2020 - Issue 3
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Review Articles

DNA methylation changes on immune cells in Systemic Lupus Erythematosus

Carolina HurtadoSchool of Graduate Studies and School of Medicine, CES University, Medellin, Colombia;
,
Liliana Yazmín Acevedo SáenzSchool of Nursery, CES University, Medellin, Colombia;
,
Elsa María Vásquez TrespalaciosSchool of Medicine, CES University, Medellin, Colombia;
,
Rodrigo UrregoGroup INCA-CES, School of Veterinary Medicine and Zootechnic, CES University, Medellin, Colombia;
,
Scott JenksDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA;
,
Iñaki SanzDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA;
&
Gloria VásquezGrupo de Inmunología Celular e Inmunogenética, University of Antioquia, Medellin, ColombiaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-0647-0906
ORCID Icon show all
Pages 114-121 | Received 27 Sep 2019, Accepted 23 Jan 2020, Published online: 04 Feb 2020
 
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Abstract

DNA methylation as a process that regulates gene expression is crucial in immune cells biology. Global and gene specific methylation changes have been described in autoimmunity, especially in Systemic Lupus Erythematosus. These changes not only contribute to the understanding of the disease, but also some have been proposed as diagnostic or disease activity biomarkers. The present review compiles the most recent discoveries on this field on each type of immune cells, including specific changes in signalling pathways, genes of interest and its possible applications on diagnosis or treatment.

Disclosure statement

This review did not receive financial support and the authors have no potential conflict of interest to declare.

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