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Immunopharmacology and Immunotoxicology Volume 28, 2006 - Issue 1
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Research Article

Peroral IMUNOR®, A Low-Molecular-Weight Immunomodulator Prepared from Disintegrated and Ultrafiltered Leukocytes, Enhances Recovery from Myelosuppression Induced by Cisplatin or 5-Fluorouracil

M. Hofer Laboratory of Experimental Hematology, Institute of Biophysics, Academy of Sciences of the Czech Republic, Czech Republic
,
A. Vacek Laboratory of Experimental Hematology, Institute of Biophysics, Academy of Sciences of the Czech Republic, Czech Republic
,
J. Holá Laboratory of Experimental Hematology, Institute of Biophysics, Academy of Sciences of the Czech Republic, Czech Republic
,
L. Weiterová Laboratory of Experimental Hematology, Institute of Biophysics, Academy of Sciences of the Czech Republic, Czech Republic
&
D. Štreitová Laboratory of Experimental Hematology, Institute of Biophysics, Academy of Sciences of the Czech Republic, Czech Republic
Pages 1-11 | Published online: 08 Oct 2008
 
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Abstract

A single dose of IMUNOR®, a low-molecular-weight immunodulator prepared from disintegrated and ultrafiltered pig leukocytes, was found to enhance recovery of murine pool of hemopoietic progenitor cells for granulocytes and macrophages damaged by a single injection of cytotoxic drugs 5-fluorouracil or cisplatin. The best results were obtained after the treatment with IMUNOR® on days 3 or 4 after the injection of 5-fluorouracil or cisplatin. These results together with previous findings obtained in our laboratory suggest that IMUNOR® has the potential to become a part of treatment schemes in oncological practice aimed at alleviation of myelosuppression evoked by cytotoxic anti-tumor therapy.

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