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Growth Factors Volume 25, 2007 - Issue 2
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Original

FGF-4 increases in vitro expansion rate of human adult bone marrow-derived mesenchymal stem cells

Jordi Farré Laboratory of Cell Physiology, Department of Cardiology-Institut Català de Ciencies Cardiovasculars, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Antoni Ma Claret 167, 08025, Barcelona, Spain; Departament d'Enginyeria Química, Escola Tècnica Superior d'Enginyeria, E.T.S.E., Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Barcelona, Spain
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Jordi Farré Laboratory of Cell Physiology, Department of Cardiology-Institut Català de Ciencies Cardiovasculars, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Antoni Ma Claret 167, 08025, Barcelona, Spain; Departament d'Enginyeria Química, Escola Tècnica Superior d'Enginyeria, E.T.S.E., Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Barcelona, Spain
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Santiago Roura Laboratory of Cell Physiology, Department of Cardiology-Institut Català de Ciencies Cardiovasculars, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Antoni Ma Claret 167, 08025, Barcelona, Spain
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Jordi Farré Laboratory of Cell Physiology, Department of Cardiology-Institut Català de Ciencies Cardiovasculars, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Antoni Ma Claret 167, 08025, Barcelona, Spain; Departament d'Enginyeria Química, Escola Tècnica Superior d'Enginyeria, E.T.S.E., Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Barcelona, Spain
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Santiago Roura Laboratory of Cell Physiology, Department of Cardiology-Institut Català de Ciencies Cardiovasculars, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Antoni Ma Claret 167, 08025, Barcelona, Spain
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Cristina Prat-Vidal Laboratory of Cell Physiology, Department of Cardiology-Institut Català de Ciencies Cardiovasculars, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Antoni Ma Claret 167, 08025, Barcelona, Spain
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Carolina Soler-Botija Laboratory of Cell Physiology, Department of Cardiology-Institut Català de Ciencies Cardiovasculars, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Antoni Ma Claret 167, 08025, Barcelona, Spain
,
Anna Llach Laboratory of Cell Physiology, Department of Cardiology-Institut Català de Ciencies Cardiovasculars, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Antoni Ma Claret 167, 08025, Barcelona, Spain
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Cristina E. Molina Laboratory of Cell Physiology, Department of Cardiology-Institut Català de Ciencies Cardiovasculars, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Antoni Ma Claret 167, 08025, Barcelona, Spain
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Leif Hove-Madsen Laboratory of Cell Physiology, Department of Cardiology-Institut Català de Ciencies Cardiovasculars, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Antoni Ma Claret 167, 08025, Barcelona, Spain
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Jordi J. Cairó Departament d'Enginyeria Química, Escola Tècnica Superior d'Enginyeria, E.T.S.E., Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Barcelona, Spain
,
Francesc Gòdia Departament d'Enginyeria Química, Escola Tècnica Superior d'Enginyeria, E.T.S.E., Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Barcelona, Spain
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Ramon Bragós Centre de Recerca en Enginyeria Biomèdica, Universitat Politècnica de Catalunya, 08034, Barcelona, Spain
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Juan Cinca Laboratory of Cell Physiology, Department of Cardiology-Institut Català de Ciencies Cardiovasculars, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Antoni Ma Claret 167, 08025, Barcelona, Spain
&
Antoni Bayes-Genis Laboratory of Cell Physiology, Department of Cardiology-Institut Català de Ciencies Cardiovasculars, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Antoni Ma Claret 167, 08025, Barcelona, SpainCorrespondence[email protected]
 show all
Pages 71-76 | Received 23 Nov 2006, Published online: 11 Jul 2009
 
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Abstract

Human bone marrow-derived mesenchymal stem cells (MSCs) exhibit limited in vitro growth. Fibroblast growth factors (FGFs) elicit a variety of biological responses, such as cell proliferation, differentiation and migration. FGF-4 represents one of the FGFs with the highest cell mitogenic activity.

We studied the effect of FGF-4 on MSCs growth and pluripotency. MSCs duplication time (Td) was significantly reduced with FGF-4 compared to controls (2.2 ± 0.2 vs. 4.1 ± 0.2 days, respectively; p = 0.03) while BMP-2 and SCF-1 did not exert a significant growth effect. MSC expression of surface markers, differentiation into adipogenic and osteogenic lineages, and baseline expression of cardiomyogenic genes were unaffected by FGF-4.

In summary, exogenous FGF-4 increases the rate at which MSC proliferate and has no significant effect on MSC pluripotency.

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