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Growth Factors Volume 25, 2007 - Issue 5
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Original

Differential expression of TGFBR3 (betaglycan) in mouse ovary and testis during gonadogenesis

Mai A. Sarraj Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, Australia
,
Mai A. Sarraj Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, Australia
,
Hui Kheng Chua Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, Australia
,
Mai A. Sarraj Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, Australia
,
Hui Kheng Chua Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, Australia
,
Alexandra Umbers Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, Australia
,
Mai A. Sarraj Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, Australia
,
Hui Kheng Chua Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, Australia
,
Alexandra Umbers Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, Australia
,
Kate L. Loveland Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Vic., 3168, Australia; The ARC Centre of Excellence in Biotechnology and Development, Melbourne, Vic., Australia
,
Mai A. Sarraj Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, Australia
,
Hui Kheng Chua Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, Australia
,
Alexandra Umbers Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, Australia
,
Kate L. Loveland Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Vic., 3168, Australia; The ARC Centre of Excellence in Biotechnology and Development, Melbourne, Vic., Australia
,
Jock K. Findlay Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, Australia
,
Mai A. Sarraj Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, Australia
,
Hui Kheng Chua Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, Australia
,
Alexandra Umbers Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, Australia
,
Kate L. Loveland Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Vic., 3168, Australia; The ARC Centre of Excellence in Biotechnology and Development, Melbourne, Vic., Australia
,
Jock K. Findlay Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, Australia
&
Kaye L. Stenvers Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic., 3168, AustraliaCorrespondence[email protected]
 show all
Pages 334-345 | Received 08 Oct 2007, Accepted 27 Nov 2007, Published online: 11 Jul 2009
 
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Abstract

TGFBR3 is an accessory receptor that binds to and modulates the activities of both transforming growth factor-beta (TGFβ) and inhibin, two members of the TGFβ superfamily of growth factors that regulate many aspects of reproductive biology. Tgfbr3 is known to be expressed in adult testis and ovary, but little is known about this receptor during gonadogenesis. Herein, we describe Tgfbr3 expression in the male and female fetal and neonatal murine gonad. Real-time PCR analysis revealed that Tgfbr3 mRNA was expressed at higher levels in the developing testis compared to ovary. TGFBR3 was expressed within the fetal testis interstitium, predominantly by Leydig cells, but expression shifted inside the seminiferous cords at birth. In contrast, TGFBR3 was detected in both the somatic and germ cell lineages in the fetal and neonatal ovary. This differential expression pattern suggests divergent roles for this TGFBR3 in developing testis and ovary.

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