https://orcid.org/0000-0002-5939-4783
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Abstract
This experimental study aimed to evaluate the effects of injectable platelet-rich fibrin (i-PRF) on mucosal healing and the release of growth factors in rats. 40 rats were used; i-PRF was administered in the right buccal area while saline was injected in the left. Cytokeratin, FGF, PDGF, TGF, and VEGF expressions were determined with immunohistochemistry. Gene expressions of EGF, TGF-β, and VEGF were analysed. Epithelialization started on the 3rd day, and connective tissue maturation was more prominent in the i-PRF-applied group. Also, the releases of VEGF, EGF, TGF-β, PDGF, and FGF were higher in the i-PRF group during the 14 days. Gene expression analysis showed that changes in TGF-β at 14 days after i-PRF injection and VEGF after 21 days were statistically significant. The results of this study suggested that autologous i-PRF application enhanced the healing of oral mucosal wounds by increasing the release of growth factors for 21 days.
Authors contributions
Conceptualisation, experiment design and execution, acquisition and analysis of data, and drafting of manuscript: ALA, GTC. Experiment design and execution, acquisition, and analysis of data: ALA, GTC, AK, NZ, ÖÖ, ŞA, DM. Study supervision, acquisition of funding, and revision of the manuscript: ALA, ŞA.
Disclosure statement
The author(s) declared no potential conflicts of interest concerning the research, authorship, and/or publication of this article. The authors alone are responsible for the content and writing of the paper.
Data availability statement
The data that supports the findings of this study is available from the corresponding author upon reasonable request.