Bilateral Uveitis Manifesting as a Complication of Chronic Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation

Abstract

Purpose: To document the rare occurrence of uveitis presumed secondary to chronic graft-versus-host disease (cGVHD). Methods: Observational case report. Results: A 52-year-old Filipino male who had undergone allogeneic BMT 10 years earlier presented with bilateral uveitis and biopsy-proven cutaneous cGVHD. There was no evidence of infection or other immune-related causes and the inflammation had a temporal correlation with his dermatological GVHD. The patient responded to treatment with oral cyclosporin A. Conclusion: The coexistence of uveitis and cGVHD is rare. The ophthalmologist should be aware of such an association and work together with the oncologist to treat these patients appropriately.

KEYWORDS:

• Uveitis
• graft-versus-host
• bone marrow transplant
• allogeneic
• visual outcome