Risk Factors for Glaucoma in a Cohort of Patients with Fuchs Heterochromic Iridocyclitis

ABSTRACT

Purpose: To describe the incidence and risk factors for ocular hypertension and/or glaucoma in patients with Fuchs heterochromic iridocyclitis (FHC).

Methods: Retrospective analysis of 88 patients with FHC. Kaplan–Meier curves estimated the time to develop cataract and ocular hypertension/glaucoma. Possible prognostic factors were investigated in univariate Kaplan–Meier analyses using the Mantel–Cox logrank test.

Results: At presentation with FHC, 52% of patients had a cataract and 26% of patients had ocular hypertension/glaucoma. The estimated percentage of patients with a cataract or ocular hypertension/glaucoma by 4 years after presentation was 71% (CI: 58–81%) and 39% (CI: 28–51%), respectively. Patients aged ≥50 years had significantly greater risk of developing glaucoma (p = 0.0065). After adjusting for age-group, having a cataract at presentation was associated with increased risk of glaucoma (p = 0.032).

Conclusions: Risk factors for development of ocular hypertension/glaucoma were increasing patient age and having a cataract at presentation with FHC.

Keywords:

• Cataract
• glaucoma
• heterochromia
• uveitis

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Funding

LL is supported by a National Health and Medical Research Council Early Career Fellowship (#1109330). The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government in Australia.

Additional information

Funding

LL is supported by a National Health and Medical Research Council Early Career Fellowship (#1109330). The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government in Australia.