Circulating S100A8/A9 Levels Reflect Intraocular Inflammation in Uveitis Patients

ABSTRACT

Purpose: To investigate whether there is an association between circulating S100A8/A9 levels and uveitis activity.

Methods: A total of 549 plasma samples were collected from uveitis patients and non-uveitic controls.

Results: S100A8/A9 plasma levels were elevated in uveitis patients compared to non-uveitic controls (P < 0.001). S100A8/A9 plasma levels in patients with active acute anterior uveitis (AAU) were significantly elevated and remarkably decreased in parallel with the severity of intraocular inflammation after corticosteroid treatment (P < 0.001). S100A8/A9 plasma levels were also higher in AAU patients with ankylosing spondylitis (AS) than in patients without AS (P = 0.02). S100A8/A9 plasma levels were significantly increased in uveitis patients with elevated C-reactive protein (CRP, P = 0.004) or erythrocyte sedimentation rates (ESR, P = 0.049) levels compared to uveitis patients with normal CRP or ESR values.

Conclusion: Circulating S100A8/A9 might be a useful biomarker for the measurement of intraocular inflammation.

Keywords:

• Biomarker
• calprotectin
• ocular inflammation
• S100A8/A9
• uveitis

Contributors

Chi ZL and Wang YQ designed the experiments. Wang YQ, Lin D, Gong XH, Fang AW, and Cui RZ recruited patients and collected blood samples. Wang YQ, Dai XD, Fang AW, Ran Y, Cao Y, Lan CL, Guan JT, Liu C, Yang FM, Gan YJ, Liu BJ, and Jin ZB carried out experiments, acquired and analyzed the data. Chi ZL, Lu F, and Qu J designed the study. Chi ZL and Dai XD drafted the manuscript.

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Additional information

Funding

This research was supported by the National Natural Science Foundation of China (81770918), and Zhejiang Provincial Natural Science Foundation of China (LY16H120006).