Serum Cortistatin Levels in Patients with Ocular Active and Ocular Inactive Behçet Disease

ABSTRACT

Purpose

To evaluate serum cortistatin (CST) levels in patients with ocular active and ocular inactive Behçet disease (BD) and its relationship with disease activity.

Methods

24 BD patients with ocular active, 24 BD patients with ocular inactive patients and 24 healthy control subjects were included in the study.

Results

In ocular active and ocular inactive BD patients and healthy control subjects, the mean serum CST levels were 4.38 ± 1.63ng/ml, 5.46 ± 1.81ng/ml and 7.56 ± 1.73ng/ml, respectively. ESR, serum CRP, CST levels and NLR were significantly different between the groups (p < 0.001 for all). The CST levels were similar between ocular active and inactive BD patient groups (p = 0.197). ESR, CRP and NLR were significantly higher in ocular active BD patients compared to ocular inactive BD patients and healthy control subjects (p < 0.05 for all).

Conclusion

Serum CST level was significantly lower in BD patients. CST may be a neuropeptide that plays a role in the pathogenesis of BD.

Keywords:

• Behçet disease
• Behçet disease ocular attack score 24
• cortistatin
• C-reactive protein
• erythrocyte sedimentation rate
• neutrophil-lymphocyte ratio

Declaration of interest

None of the authors has a conflict of interest with or source of funding for the submission.

Additional information

Funding

No financial support was received for this submission.