Comparison of Optical Coherence Tomography Angiography Findings in Patients with Behçet’s Disease and Healthy Controls

ABSTRACT

Purpose

To investigate optical coherence tomography angiography (OCTA) findings in patients with Behçet’s disease (BD).

Methods

Ninety-four eyes of 49 patients with BD and 53 eyes of 53 healthy subjects were included. Vascular density (VD), foveal avascular zone (FAZ) area, perifoveal capillary hypoperfusion, perifoveal capillary network disorganization, and FAZ irregularity were analyzed.

Results

OCTA revealed retinal VD reduction and higher perifoveal capillary hypoperfusion, perifoveal capillary network disorganization and FAZ irregularity in ocular Behçet’s compared to nonocular Behçet’s (p = .000). However, compared to normal eyes, there was no difference between any OCTA measurements in nonocular BD patients. The mean area of FAZ was not different in any group (p = .266). In ocular Behçet, visual acuity was inversely correlated with FAZ area and FAZ irregularity.

Conclusion

Retinal VD decreases and perifoveal microvascular network changes in ocular Behçet’s. FAZ irregularity may be a more valuable marker than FAZ area for indicating ocular involvement.

Keywords:

• Behçet’s disease
• foveal avascular zone
• optical coherence tomography angiography
• retinal microvasculature
• vascular density

Financial disclosures

The authors have no financial or proprietary interest in a product, method or material described here.

Declaration Of Interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Additional information

Funding

The authors did not receive any financial support from any public or private source.