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Ocular Immunology and Inflammation Volume 28, 2020 - Issue sup1: COTS supplement
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Original Articles

Visual Morbidity in Ocular Tuberculosis – Collaborative Ocular Tuberculosis Study (COTS)-1: Report #6

Rupesh Agrawal MD, FCRSa National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore;b Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK;c School of Medicine, National University of Singapore, Singapore, Singapore;d Singapore Eye Research Institute, Singapore, SingaporeORCID Iconhttps://orcid.org/0000-0002-6662-5850
ORCID Icon,
Dinesh Visva Gunasekeran MBBSa National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore;b Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK;c School of Medicine, National University of Singapore, Singapore, Singapore
,
Aniruddha Agarwal MSe Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaORCID Iconhttps://orcid.org/0000-0003-4985-9855
ORCID Icon,
Ilaria Testi MDb Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK
,
Ester Carreño MDf Departamento de Oftalmologiía, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain
,
Mark Westcott FRCOphthb Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK
,
Sarakshi Mahajan MBBSg Byers Eye Institute, Stanford University, Palo Alto, California, USA
,
Dhananjay Raje PhDh MDS Bioanalytics, India
,
Kanika Aggarwal MSe Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
,
Somasheila I Murthy DNBi Tej Kohli Cornea Institute, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India
,
Soon-Phaik Chee FRCSEda National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore;d Singapore Eye Research Institute, Singapore, Singapore;j Singapore National Eye Centre, Singapore, Singapore;k Department of Ophthalmology & Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore
,
Peter Mccluskey MDl Department of Clinical Ophthalmology & Eye Health, Central Clinical School, Save Sight Institute, the University of Sydney, Sydney, Australia
,
Su Ling Ho FRCSGlasga National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore
,
Stephen Teoh FRCSEda National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore
,
Luca Cimino MDm Ocular Immunology Unit, Azienda USL IRCCS, Reggio Emilia, ItalyORCID Iconhttps://orcid.org/0000-0001-7956-9950
ORCID Icon,
Jyotirmay Biswas MSn Department of Ophthalmology, Sankara Nethralaya, Chennai, India
,
Shishir Narain MDo Department of Ophthalmology, Shroff Eye Centre, New Delhi, India
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Manisha Agarwal MSp Department of Ophthalmology, Dr Shroff’s Charity Eye Hospital Daryaganj, New Delhi, India
,
Padmamalini Mahendradas DNBq Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, India
,
Moncef Khairallah MDr Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Tunisia
,
Nicholas Jones FRCSOphths Department of Ophthalmology, University of Manchester, Manchester, UK
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Ilknur Tugal-Tutkun MDt Istanbul Faculty of Medicine, Department of Ophthalmology, Istanbul University, TurkeyORCID Iconhttps://orcid.org/0000-0002-4020-453X
ORCID Icon,
Kalpana Babu DNBu Prabha Eye Clinic & Research Centre, Vittala International Institute of Ophthalmology, Bangalore, India
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Soumayava Basu MSf Departamento de Oftalmologiía, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain;v Department of Ophthalmology, LV Prasad Eye Institute, Bhubaneswar, India
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Richard Lee PhDb Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK
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Hassan Al-Dhibi MDw Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
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Bahram Bodaghi MDx Department of Ophthalmology, DHU SightRestore, Sorbonne University, Paris, France
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Alessandro Invernizzi MDy Department of Biomedical and Clinical Science “L. Sacco”, Eye Clinic, Luigi Sacco Hospital, University of Milan, ItalyORCID Iconhttps://orcid.org/0000-0003-3400-1987
ORCID Icon,
Debra A. Goldstein MDz Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
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Carl P. Herbort MDaa Centre for Ophthalmic Specialised Care & University of Lausanne, Lausanne, Switzerland
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Talin Barisani-Asenbauer PhDbb The Centre for Ocular Inflammation and Infection (OCUVAC), Laura Bassi Centre of Expertise Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
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Julio J González-López PhDcc Department of Ophthalmology, Ramón Y Cajal University Hospital, Madrid, SpainORCID Iconhttps://orcid.org/0000-0001-7210-7809
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Sofia Androudi MDdd Department of Ophthalmology, University of Thessaly, GreeceORCID Iconhttps://orcid.org/0000-0002-5303-7793
ORCID Icon,
Reema Bansal MSe Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
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Bruttendu Moharana MSe Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
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Simona Degli Esposti MDb Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK
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Anastasia Tasiopoulou MDb Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK
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Sengal Nadarajah MDb Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK
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Mamta Agarwal DNBn Department of Ophthalmology, Sankara Nethralaya, Chennai, India
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Sharanaya Abraham MDn Department of Ophthalmology, Sankara Nethralaya, Chennai, India
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Ruchi Vala MDq Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, India
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Ramandeep Singh MSe Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
,
Aman Sharma MDee Department of Rheumatology, PGIMER, Chandigarh, India
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Kusum Sharma PhDff Department of Microbiology, PGIMER, Chandigarh, India
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Manfred Zierhut PhDgg Centre of Ophthalmology, Department of Ophthalmology, University of Tuebingen, Tuebingen, Germany
,
Onn Min Kon MRCPhh Chest and Allergy Clinic, St Mary’s Hospital, Imperial College Healthcare NHS Trust, London, UK
,
Emmett T. Cunningham PhDii The Francis I. Proctor Foundation, UCSF School of Medicine, San Francisco, California, United States
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John H. Kempen PhDjj Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States;kk MCM Eye Unit, MyungSung Christian Medical Center and MyungSung Medical School, Addis Ababa, Ethiopia
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Quan Dong Nguyen PhDg Byers Eye Institute, Stanford University, Palo Alto, California, USA
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Carlos Pavesio FRCSOphthb Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK
&
Vishali Gupta MSe Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaCorrespondence[email protected]
 show all
Pages 49-57 | Received 12 Dec 2019, Accepted 24 May 2020, Published online: 30 Jun 2020
 
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1

ABSTRACT

Objective: Aim of the study was to examine extent, natural history, and clinical features associated with visual impairment (VI) in patients diagnosed with ocular tuberculosis (OTB) by the Collaborative Ocular Tuberculosis Study (COTS)-1.

Methods: Multi-center retrospective cohort study. Main outcomes were VI.

Results: A total of 302 patients were included in the study, including 175 patients whose data related to BCVA were available throughout the 2 years of follow up. Mean BCVA grossly improved at 12, 18, and 24 months of follow-up (p < .001). Mean BCVA was worse at 12–18th month follow-up for patients treated with ATT versus patients who were not treated with ATT, but patients treated with ATT had a statistically significant improvement in BCVA at the 24-month endpoint.

Conclusions: OTB is associated with significant visual morbidity, future well-designed prospective studies are warranted to establish the causal association between OTB and visual loss.

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