Association of Killer Cell Immunoglobulin-like Receptor and Human Leukocyte antigen-C Genotype with HLA-B27 Associated Acute Anterior Uveitis and Idiopathic Acute Anterior Uveitis in a Chinese Han Population

ABSTRACT

Purpose

whether killer cell immunoglobulin-like receptors (KIRs) and human leukocyte antigens C (HLA-C) are associated with HLA-B27 associated acute anterior uveitis (B27AAU) and idiopathic AAU (IAAU) remains unclear.

Methods

PCR with sequence-specific primers was used to analyze KIR genes and HLA-C alleles in a Chinese Han population of 196AAU patients and 210 control subjects.

Results

The higher frequencies of HLA-C2 and KIR2DL1/HLA-C2 (p = .009 and p = .044, respectively) and the lower frequencies of HLA-C1C1 and HLA-C1 (p = .034 and p = .009, respectively) were observed in B27AAU than control group. The higher frequencies of KIR2DL2 and KIR2DL2/HLA-C1 (p = .009 and p = .044, respectively) and the lower frequencies of KIR2DL3 and KIR2DL3/HLA-C1 (p = .000 and p = .001, respectively) were observed in IAAU than control group.

Conclusions

HLA-C2 and KIR2DL1/HLA-C2, KIR2DL2, and KIR2DL2/HLA-C1 might be susceptible for B27AAU and IAAU, respectively. HLA-C1C1 and HLA-C1, KIR2DL3 and KIR2DL3/HLA-C1 might protect from B27AAU and IAAU, respectively.

KEYWORDS:

• Killer cell immunoglobulin-like receptor
• human leukocyte antigens C
• genotype
• acute anterior uveitis

AUTHOR CONTRIBUTIONS

Study design (YXL, GFR); data collection (YXL,NG); analysis and interpretation of data (YXL, MHX, GFR); writing the manuscript (YXL, GFR); statistical expertise (YXL, MHX).

DECLARATION OF INTEREST

The authors declare no conflict of interest. The authors alone are responsible for the content and writing of the article.

SUPPLEMENTARY MATERIAL

Supplemental data for this article can be accessed on the publisher’s website.