ABSTRACT
Purpose
To investigate the retinal nerve fiber layer thickness (RNFLT) in uveitic eyes and search for the associations with uveitis activity, etiology and location.
Methods
The files of 76 patients with uveitis and 76 controls were scanned. Associations of RNFLT were analyzed using generalized linear models.
Results
The RNFLT was significantly higher in patients with uveitis (p < .001). Active uveitis patients had a thicker RNFL than the controls and the patients with quiescent uveitis (p < .001). Anterior uveitis was associated with thinner RNFL in global and inferotemporal quadrant (p = .011 and 0.013, respectively). Thickening of RNFL was associated with posterior uveitis and Behçet’s disease in all quadrants (p < .001) and idiopathic uveitis in the superonasal and nasal quadrants (p = .001).
Conclusion
Active uveitis, as well as posterior uveitis and Behcet’s disease-associated uveitis, is a major confounding factor in RNFL analysis and therefore detection of glaucoma.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper
The orcid ids and the e-mail adresses of the authors
Hayati Yilmaz: 0000-0001-5051-5713/[email protected]
Mehmet Talay Koylu: 0000-0002-7283-3760/[email protected]
Bağım Ayçin Çakır: 0000-0002-3108-6295/[email protected]
Murat Küçükevcilioğlu: 0000-0001-7776-2183/[email protected]
A.Hakan DURUKAN: 0000-0001-6571-6155/[email protected]
Atilla Bayer: 0000-0002-0184-8033/[email protected]
Fatih Mehmet Mutlu: 0000-0002-7796-6511/[email protected]