Uveal and Conjunctival Malignant Melanoma in Denmark, 1943–97: Incidence and Validation Study

Abstract

Purpose: To study the incidence of malignant melanoma in the ocular region in Denmark during the period 1943-97. Methods: The patients were mainly identified through the Danish Cancer Registry. Age-period-cohort modelling of the incidence rates was done based on age at diagnosis, calendar period and birth cohort in 5-year groups and for each gender. Results: The age-standardized incidence of malignant melanoma in the ocular region was 0.78 for men (N = 1327) and 0.65 for women (N = 1242) per 100,000 person-years. Calendar period and birth cohort had no effect on the incidence in the ocular region or in the topography subgroups choroid/ciliary body and conjunctiva. However, the incidence increased with birth cohort for iris melanomas. Conclusions: The incidence of malignant melanoma in the ocular region was stable in contrast to a major increase in cutaneous melanoma in Denmark during the period 1943-97. The incidence of iris melanomas increased substantially, whereas the rate was stable for choroid/ciliary body and conjunctival melanomas.

KEYWORDS:

• Malignant melanoma
• uveal melanoma
• conjunctival melanoma
• age-period-cohort models
• Danish Cancer Registry
• tumor incidence
• Denmark