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Abstract
The medicinal value of Withania somnifera root powder on the circadian variations of gentamicin (GEN)-induced nephrotoxicity was explored in this study. The circadian characterstics of 24 h rhythms such as acrophase, amplitude and mesor of renal biomarkers (urea and creatinine), blood glucose, protein and cholesterol were analyzed. In GEN treated rats, elevated levels of circulatory biomarkers-glucose, protein and cholesterol (increased mesor) were observed. In contrast treatment with W. somnifera significantly restored these levels (decreased mesor). Variations in amplitude and ‘r’ values also were observed in between the nephrotoxic rats and other experimental groups. Therefore, we conclude that W. somnifera alter the circadian variations directly with its valuable bioactive compounds, which could pave a way for future investigation for therapeutic approach.