Low level of Nesfatin-1 is associated with gestational diabetes mellitus

Abstract

Introduction: Gestational diabetes mellitus (GDM) occurs in ∼10–25% of pregnancies. Nesfatin-1, plays a role in carbohydrate metabolism by inhibiting glucagon secretion, besides has a glucose-dependent insulinotropic effect. Explanation of the GDM pathogenesis is important due to preventing gestational complications. We aimed to investigate relationship between GDM and Nesfatin-1.

Material and methods: Seventy-nine pregnant subjects were randomly allocated to either GDM group (GDG, n = 38) or control group (CG, n = 41). For GDM diagnosis, 50 and 100 g oral glucose tolerance test (OGTT) were used. Nesfatin-1, insulin and other parameters were measured for all subjects. The homeostasis model assessment-insulin resistance (HOMA-IR) was calculated.

Results: Nesfatin-1 was found lower and insulin was found higher in GDG than CG. Negative correlation has been founded between Nesfatin-1 with weight, BMI, fasting glucose, serum glucose level at first hour of the 50 g OGTT and HOMA-IR.

Conclusion: In this study, patients with GDM had lower Nesfatin-1 levels than without GDM. Therefore, when the Nesfatin-1 effects on the GDM pathogenesis is clear, it may be contributed to diagnosis and treatment of the GDM.

Chinese abstract

引言: 妊娠期糖尿病发生在10-25%的妊娠中。除了通过葡萄糖依赖性促胰岛素分泌效应外, Nesfatin-1还通过抑制胰高血糖素的分泌在碳水化合物的代谢中起作用。由于与预防妊娠期并发症有关, 所以GDM的发病机制的阐释十分重要。本研究目的是研究GDM与Nesfatin-1的关系。

材料及方法: 79名妊娠女性随机分到GDM组(GDG, n =38) 或对照组(CG, n =41) 。GDM的诊断采用50和100克口服葡萄糖耐量试验(OGTT) 。所有研究对象都检测Nesfatin-1、胰岛素和其他参数。并计算稳态模型评估的胰岛素抵抗指数(HOMA-IR) 。

结果: 研究发现GDM组Nesfatin-1水平低于对照组, 胰岛素水平则高于对照组。Nesfatin-1与体重、BMI、空腹血糖、50克OGTT试验1小时静脉血糖水平和HOMA-IR指数负相关。

结论: 本研究中, GDM患者Nesfatin-1水平低于非GDM患者。因此, 当Nesfatin-1对GDM发病机制的作用明确后, 它可能有助于GDM的诊断和治疗。

Keywords:

• Gestational diabetes mellitus
• insulin resistance
• Nesfatin-1

Acknowledgements

This work was supported by Hitit University [grant number: TIP 19003.14.001].

Declaration of interest

The authors declared no conflict of interests.