Abstract
Objective: The present study was designed to evaluate the association between anti-Mullerian hormone (AMH) and insulin resistance (IR) in non-obese adolescent females with polycystic ovary syndrome (PCOS) with and without IR.
Methods: Seventy-seven consecutive non-obese patients were recruited and distributed into three groups according to diagnoses of PCOS and IR. Group I included 27 females diagnosed with PCOS and IR, group II included 18 females diagnosed with PCOS but without IR, and group III included 32 controls without PCOS.
Results: Group I had significantly higher AMH levels compared to group II and group III (p < 0.012 and p < 0.000, respectively). ROC curve analyses demonstrated that the AUC, indicative of the AMH value for discriminating PCOS with IR, was 0.763, with a confidence interval of 0.607–0.920 (p = 0.004). There was a significant positive correlation between serum AMH and HOMA-IR levels in adolescent females with PCOS (p = 0.003).
Conclusion: We found that serum AMH levels were higher in non-obese adolescent females with PCOS and IR than in PCOS patients without IR and the healthy controls. There was a significant positive correlation between AMH levels and IR in non-obese adolescent females with PCOS.
Chinese abstract
目的: 本研究旨在评估患有多囊卵巢综合征 (PCOS) 的非肥胖青少年女性有无IR时抗苗勒管激素 (AMH) 和胰岛素抵抗 (IR) 之间的关系。
方法: 根据PCOS和IR的诊断, 连续招募77名非肥胖患者并分为三组。 I组包括27名诊断为PCOS和IR的女性, II组包括18名诊断为PCOS但无IR的女性, III组包括32名无PCOS的对照。
结果: 与组II和组III相比, 组I具有显著更高的AMH水平 (分别为p < 0.012和p < 0.000) 。ROC曲线分析表明, 用IR鉴别PCOS的AMH值的AUC为0.763, 置信区间为0.607-0.920 (p = 0.004) 。 在具有PCOS的青少年女性中, 血清AMH和HOMA-IR水平之间存在显着的正相关 (p = 0.003) 。
结论: 我们发现, 与没有IR的PCOS和健康对照组相比, 具有PCOS和IR的非肥胖青春期女性的血清AMH水平更高。在具有PCOS的非肥胖青春期女性中, AMH水平和IR之间存在显着的正相关。
Declaration of interest
The authors report no declarations of interest.