Abstract
Irisin regulates glucose levels, lipid levels, insulin sensitivity, and low-grade inflammation. Gestational diabetes mellitus (GDM) is a common metabolic complication of pregnancy, and is associated with increased rates of perinatal problems. Oxidative stress biomarkers have a role in the pathogenesis of patients with GDM. In total, 94 patients were included in our study including 46 control patients and 48 patients with GDM. Fasting blood glucose, HOMA-IR, total oxidative stress (TOS), irisin, and oxidative stress index (OSI) levels of the patients were measured. Serum OGTT, OSI, irisin HOMA, TOS, and insulin levels were statistically significantly higher in the patient group than in the control group. This was the first study to investigate the relation between serum irisin levels and oxidative stress markers in patients with GDM. The results revealed that irisin is an oxidative stress marker and a metabolic protective hormone.
Chinese abstract
鸢尾素调节血糖水平、血脂水平、胰岛素敏感性和低度炎症反应。妊娠期糖尿病 (GDM) 是一种常见的妊娠期代谢并发症, 它的出现增加了围产医学问题。氧化应激标志物在GDM患者的发病机制中起作用。研究共纳入94例患者, 其中46例为对照组, 48例为GDM患者。测量所有患者的空腹血糖、胰岛素抵抗指数 (HOMA-IR) 、总氧化应激能力 (TOS) 、鸢尾素水平和氧化应激指数 (OSI) 。实验组患者血清口服糖耐量试验(OGTT)、OSI、鸢尾素稳态模型 (irisin HOMA) 、TOS和胰岛素水平在统计学上显著高于对照组。这是关于GDM患者血清鸢尾素水平与氧化应激标志物之间关系的第一项研究。结果表明, 鸢尾素是一种氧化应激标志物和代谢保护性激素。
Declaration of interest
The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. The authors have no direct or indirect commercial, financial incentive associated with publishing this article.