Isolated polyhydramnios in the third trimester: is a gestational diabetes evaluation of value?*

Abstract

We evaluated implications of testing for gestational diabetes mellitus (GDM) in pregnancies complicated by third trimester isolated polyhydramnios with previous negative diabetes screening test. In this retrospective cohort study of 104 pregnant women with polyhydramnios between 2005 and 2013, all had normal first trimester fasting glucose and normal glucose challenge test (GCT < 140 mg/dL). Late onset GDM was diagnosed in five women (4.8%) with isolated polyhydramnios, one abnormal value in the oral glucose tolerance test (OGTT) was identified in four additional women (3.8%). No significant differences were found in risk factors for GDM, mean second trimester GCT (117.5 vs. 107.2 mg/dL, p = 0.38) or fasting glucose values (82 vs. 86 mg/dL, p = 0.29) between women in the polyhydramnios group with and without late GDM diagnosis. Moreover, no significant difference was found in relation to the mode of delivery or birth weight between the studied groups (3437 ± 611 vs. 3331 ± 515 g, p = 0.63). Diagnosis of third trimester polyhydramnios was not associated with increased risk for GDM or neonatal complications.

Chinese abstract

我们评估了先前糖尿病筛查试验阴性的妊娠糖尿病（GDM）对妊娠合并单纯的妊娠晚期羊水过多的影响。我们对2005年至2013年间的104例羊水过多的孕妇进行回顾性队列研究, 其均有正常的妊娠中期空腹血糖和正常葡萄糖检测（GCT <140 mg/dL）。其中五名孤立的羊水过多女性（4.8％）诊断出晚发性GDM, 另外四名女性（3.8％）确定了具有口服葡萄糖耐量试验（OGTT）中的一个异常值。在具有和不具有晚期GDM诊断的羊水过多妇女中, GDM的风险因素, 平均妊娠中期GCT（117.5 vs. 107.2 mg/dL, p = 0.38）或空腹血糖值（82 vs. 86 mg/dL, p = 0.29）没有显着差异。此外, 研究组之间的分娩模式或出生体重相互比较, 没有发现显着性差异（3437 ± 611 vs.3331 ± 515g, p = 0.63）。 晚期妊娠单纯羊水过多的诊断与GDM或新生儿并发症的风险增加无关。

Keywords:

• Delivery
• gestational diabetes
• neonatal outcome
• polyhydramnios
• third trimester

Declaration of interest

There are no conflicts of interest or relationships (for any author) that may influence the objectivity of the paper.

There are no sources of funding in this study.