The use of inositol(s) isomers in the management of polycystic ovary syndrome: a comprehensive review

Abstract

The aim of this review is to present the current data about the role of inositols in the management of polycystic ovary syndrome (PCOS) women and in the prevention and treatment of gestational diabetes mellitus (GDM). We analyzed the available literature with key words PCOS, Myo-inositol, D-chiro-inositol, assisted reproductive technologies and GDM. The most recent literature would suggest that Myo-inositol, D-chiro-inositol and their combination in physiological ratio 40:1 could represent an important therapeutic strategy for the improvement of metabolic, hormonal and reproductive aspects of PCOS. In assisted reproductive technologies, however, myo-inositol and the combined treatment, despite D-chiro-inositol monotherapy, are able to improve clinical outcomes. Myo-inositol monotherapy results more effective in preventing and treating GDM even if a larger cohort of studies is needed to better clarify these results.

Chinese abstract

这篇综述的目的是阐述肌醇在管理多囊卵巢综合征 (PCOS) 以及预防和治疗妊娠期糖尿病 (GDM)的作用。我们分析了以PCOS、肌醇、手性肌醇、辅助生育技术和妊娠期糖尿病为关键词可获得的文献。最新的文献表明肌醇、手性肌醇以及两者按40：1组成的化合物能够改善PCOS患者的代谢、激素分泌以及生育力。在辅助生育技术领域, 无论是手性肌醇的单药治疗还是肌醇的联合治疗, 都能改善临床结局。肌醇的单药治疗在预防和治疗GDM中更有效, 但这一结论仍需多中心大样本的研究来进一步证实。

Keywords:

• PCOS
• myo-inositol
• D-chiro-inositol
• assisted reproductive techniques
• GDM

Disclosure statement

The authors report no conflict of interest.