Motivational interviewing in obese women with polycystic ovary syndrome – a pilot study

Abstract

Lifestyle intervention is first line treatment in obese women with polycystic ovary syndrome (PCOS). The effect of motivational interviewing (MI) as add on to standard advice (SA) on weight loss and quality of life (QoL) has not been evaluated in obese women with PCOS. We aimed to examine whether MI as add on to SA induced higher weight loss and improved QoL in obese women with PCOS. Thirty-seven obese women with PCOS (BMI ≥30 kg/m2) were randomized to MI + SA (n = 19) vs. SA (n = 18) for six months. Anthropometric measures (BMI, waist) and questionnaires (World Health Organization-5 (WHO-5), Major Depression Index (MDI), Short Form-36 (SF-36) and PCOS-Questionnaire (PCOS-Q)) were performed at baseline and at follow-up, www.clinicaltrials.gov, NCT02924025. Twenty-eight (14 + 14) women completed the study. At baseline, 24/28 women had WHO-5 scores <67 and 12/28 women had MDI scores indicating depression. Changes in weight and QoL were similar between MI + SA vs. SA group. However, WHO-5 (p=.028) and MDI (p=.008) scores improved significantly in the 12/24 women with MDI scores indicating depression. MI as add on to SA did not improve QoL or weight loss. Obese women with PCOS had low QoL.

摘要

生活方式干预是多囊卵巢综合征（PCOS）肥胖患者的一线治疗。在PCOS肥胖患者中, 动机性访谈（MI）对减肥和生活质量（QoL）的标准建议（SA）的影响尚未进行评估。我们的目的是评估动机性访谈添加到标准建议是否会导致肥胖PCOS患者的体重减轻和生活质量提高。37例肥胖PCOS女性（BMI≥30kg/ m²）随机分为MI + SA组（n = 19）和SA组（n = 18）, 共研究6个月。在基线评估和随访中, 观测人体测量指标（BMI, 腰围）及问卷（世界卫生组织-5（WHO-5）, 重度抑郁指数（MDI）, 简表-36（SF-36）及PCOS-问卷（PCOS-Q））, http://www.clinicaltrials.gov, NCT02924025。 28（14 + 14）名女性完成了这项研究。在基线调查中, 24/28名女性的WHO-5评分<67, 而12/28名女性的MDI评分表明有抑郁。MI + SA与SA组的体重和QoL变化相似。 然而, 在12/24名MDI得分提示抑郁的女性中, WHO-5（p =0 .028）和MDI（p =0.008）得分显着改善。添加到标准建议的动机性访谈不能改善生活质量或减轻体重。肥胖的PCOS患者生活质量低下。

Keywords:

• Polycystic ovary syndrome
• body mass index
• motivational interview
• obesity
• quality of life

Disclosure statement

The authors report no conflicts of interest.