Association of luteinizing hormone/choriogonadotropin receptor gene polymorphisms with polycystic ovary syndrome risk: a meta-analysis

Abstract

To investigate the association between Luteinizing hormone/choriogonadotropin receptor (LHCGR) gene polymorphisms and polycystic ovary syndrome (PCOS). A systematic literature search and meta-analysis using STATA software for included studies. Fourteen case-control studies containing rs13405728, rs4539842, and rs2293275 of LHCGR gene were included, which was comprised of 11,738 PCOS cases and 35,329 controls. Results of the meta-analysis showed a significant association between PCOS and rs13405728 (for G vs. A: OR = 0.735, 95% CI = 0.699–0.773, p<.001; For GG vs. AG + AA: OR = 0.578, 95% CI = 0.436–0.767, p<.001; For GG + AG vs. AA: OR = 0.817, 95% CI = 0.741–0.901, p<.001) in Asian populations, and rs4539842 (for ins/ins vs. ins/non + non/non: OR = 0.686, 95% CI = 0.483–0.974, p=.035) and rs2293275 (for AA vs. AG + GG: OR = 4.115, 95% CI = 1.033–16.38, p=.045) in Caucasian populations, respectively. LHCGR gene variations are population specifically associated with PCOS, which indicated these SNPs in LHCGR may contribute to the pathogenesis of PCOS and could be used as potential biomarkers to predict the risk of PCOS.

摘要

本研究目的是探索促黄体激素/绒毛膜促性腺激素受体（LHCGR）基因多态性与多囊卵巢综合征（PCOS）的关系。使用STATA软件进行系统的文献检索和荟萃分析。本研究包括含有LHCGR基因的rs13405728, rs4539842和rs2293275的14个病例对照研究, 共包含11,738个PCOS病例和35,329个对照对象。荟萃分析结果显示, 在亚洲人群中, rs13405728之间存在显著相关性（G与A：OR = 0.735,95％CI = 0.699-0.773, p <0.001;GG与AGþAA：OR = 0.578,95％ CI = 0.436-0.767, p <0.001;GGþAG与AA：OR = 0.817,95％CI = 0.741-0.901, p <0.001）；而在高加索人群中, PCOS与rs4539842（ins / ins与ins /nonþnon/ non：OR = 0.686,95％CI = 0.483-0.974, p = .035）和rs2293275（对于AA与AGþGG：OR = 4.115,95％CI = 1.033-16.38, p = 0.045）存在显著相关性。LHCGR基因变异是特异与PCOS相关的, 其表明LHCGR中的这些多态性可能在PCOS的发病机制中起作用, 并且可以用作预测PCOS风险的潜在生物标志物。

Keywords:

• LHCGR
• PCOS
• gene polymorphism
• association
• meta-analysis

Disclosure statement

The authors declare that they have no conflict of interest.

Additional information

Funding

The authors would like to thank financial support from Key Lab for Clinical Anatomy & Reproductive Medicine of Hengyang City (2017KJ182). S. T. was also partially supported by a grant from University of South China (2014XQD22) and a fellowship from Chinese Scholarship Council while preparing this manuscript (201608430251).