Elevation of the adiponectin/leptin ratio in women with gestational diabetes mellitus after supplementation with alpha-lipoic acid

Abstract

Alpha-lipoic acid (ALA) is a short chain fatty acid and is known as a universal antioxidant. The aim of the current clinical trial study was to explore the effects of ALA supplementation on maternal circulating values of adiponectin (A), leptin (L); and A/L, L/A, adiponectin/homeostatic model assessment for insulin resistance (A/H), and malondialdehyde/total antioxidant capacity (MDA/TAC) ratios in pregnant women with gestational diabetes mellitus (GDM). Sixty women diagnosed as GDM during 24 and 28 weeks of pregnancy were randomly divided into drug (n = 30) and placebo (n = 30) groups. They consumed ALA (100 mg) and cellulose acetate (100 mg) respectively for 8 weeks, per day. The biochemical variables were evaluated before and after the trial. Maternal fasting serum values of glucose (p < .001), HOMA-IR (p < .001), MDA/TAC (p < .001), and L/A (p = .008) were decreased while values of adiponectin (p = .011), A/L (p = .001), and A/H (p < .001) were increased in the drug group after the intervention. In summary, current study had shown that after daily supplementation with 100 mg of ALA for 8 weeks in women with GDM, maternal circulating values of adiponectin, A/L, and A/H were increased while values of L/A and MDA/TAC were decreased.

Trial registration: Iranian Registry of Clinical Trials identifier: IRCT2017091225949N5.

摘要

ɑ硫辛酸 (ALA)是一种短链脂肪酸, 被称为通用的抗氧化剂。目前临床试验研究的目的是探讨ALA补充剂对脂联素(A)、瘦素(L)母体循环值的影响；和A/L、L/A、脂联素/稳态模型评估妊娠期糖尿病（GDM）孕妇的胰岛素抵抗 (A/H)和丙二醛/总抗氧化能力(MDA/TAC)比值。60名在妊娠24周和28周被诊断为GDM的妇女被随机分为药物组(n¼30)和安慰剂组(n¼30)。她们分别每天服用ALA(100毫克)和醋酸纤维素(100毫克), 持续8周。在试验前后对生化变量进行了评估。干预后的药物组孕妇空腹血清葡萄糖值 (p <0.001),HOMA-IR (p <0.001),MDA / TAC (p <0.001)和L /A (p¼<0.008)下降,而脂联素 (p¼<0.0 11)、 A / L (p¼ <0.008)和A/H 值(p<0.001)升高。综上所述, 本研究表明：GDM妇女每日补充100mg ALA 8周后, 脂联素母体循环值、A/L、A/H值升高, 而L/A、MDA/TAC值降低。

Keywords:

• Alpha-lipoic acid
• adiponectin
• leptin
• oxidative stress
• gestational diabetes

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors gratefully acknowledge the Research Council of Arak University of Medical Sciences for the financial support [Grant Number: 2846].