Luteal phase support with GnRH agonist does not eliminate the risk for ovarian hyperstimulation syndrome

Abstract

This study aims to report a case of early, severe ovarian hyperstimulation syndrome (OHSS) following GnRH agonist trigger for final oocyte maturation despite luteal support with a GnRH agonist. Contrary to the claim that luteal support using a GnRH agonist eliminates the risk for OHSS in high-risk patients, this report alerts practitioners to the risk of severe OHSS development despite GnRH agonist luteal support in patients receiving GnRH antagonist protocol with GnRH agonist triggering and cautions the practitioners to consider other measures of OHSS prevention.

摘要

本研究的目的是报告一例虽然选用GnRH激动剂进行黄体支持触发卵母细胞成熟, 但仍伴发早期, 严重的卵巢过度刺激综合征(OHSS)的患者。这与公认的使用GnRH激动剂进行黄体支持能够降低高危患者患OHSS风险不一致, 本病例报道提醒医务工作者应用GnRH拮抗剂方案后应用GnRH激动剂进行黄体支持可能仍会伴发严重的OHSS并促使医务工作者考虑其他的OHSS预防措施。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• GnRH antagonist
• GnRH agonist
• GnRH agonist trigger
• OHSS
• luteal support

Disclosure statement

The authors declare that they have no conflict of interest