Abstract
Kisspeptin has been shown to participate in the regulation of pituitary hormone secretion and energy metabolism. In PCOS patients, there are disorders in pituitary hormone secretion and energy metabolism. The aim of this study was to investigate the serum kisspeptin and its relationship with abnormal metabolism in PCOS. This restrospective case–control study included 73 cases with PCOS and 63 control cases. All subjects were divided into obese and nonobese groups based on BMI. The serum kisspeptin levels, Cor, DHEA-S, plasma concentrations of glucose were tested. We found that the level of kisspeptin in PCOS group was higher than it in control group. The kisspeptin levels in nonobese PCOS group increased most obviously over than the other groups. The kisspeptin levels of all the subjects were positively correlated with LH levels, negatively correlated with the glucose-AUC, the insulin-AUC, and triglyceride levels. The findings of this study suggest that kisspeptin may play an important role in ovulation disorders in PCOS patients through regulating the level of LH and it could regulate the body's energy metabolism by regulating glucose and lipid metabolism.
Chinese abstract
神经激肽B已被证明参与垂体激素分泌和能量代谢。多囊卵巢综合征患者垂体激素分泌和能量代谢紊乱。本研究旨在讨论PCOS患者血清神经激肽B及其与代谢异常的关系。本研究包括73例多囊卵巢综合征患者和63例对照组。所有受试者根据体重指数分为肥胖组和非肥胖组。测定血清神经激肽B、皮质醇、脱氢表雄酮、血浆葡萄糖浓度。我们发现, 多囊卵巢综合征组的神经激肽B水平高于对照组。非肥胖组的神经激肽B水平明显高于其他组。所有受试者的神经激肽B水平与LH水平呈正相关, 与葡萄糖-曲线下面积、胰岛素-曲线下面积和甘油三酯水平呈负相关。本研究结果表明, 神经激肽B可能通过调节黄体生成素水平在多囊卵巢综合征患者排卵障碍中发挥重要作用, 并通过调节葡萄糖和脂质代谢来调节机体能量代谢。
Acknowledgements
This work was part of the Program on Effect of visfatin/insulin in endometrium with polycystic ovary syndrome patients via PI3K and ERK pathway.
Disclosure statement
No potential conflict of interest was reported by the authors.