Differential insulin response to oral glucose tolerance test (OGTT) in overweight/obese polycystic ovary syndrome patients undergoing to myo-inositol (MYO), alpha lipoic acid (ALA), or combination of both

Abstract

Polycystic ovary syndrome is characterized by several endocrine impairments, insulin resistance and hyperinsulinemia. We aimed to evaluate the effects of myo-inositol (MYO), alpha-lipoic acid (ALA) and a combination of both. Setting: retrospective study. Ninety overweight/obese patients were considered. Presence or absence of first grade diabetic relatives was checked. Patients were administered MYO (1 g/die per os), ALA (400 mg/die per os), MYO (1 gr/die) + ALA (400 mg/die) per os. Only 76 out of 90 patients completed the 12 weeks of treatment. Patients were evaluated before and after the treatment interval for LH, FSH, E2 (estradiol), A (androstenedione), T (testosterone) plasma levels, oral glucose tolerance test (OGTT). All treatments demonstrated specific positive effects: MYO modulated more hormonal profiles and OGTT in polycystic ovary syndrome (PCOS) with no familial diabetes, ALA improved insulin response to OGTT and metabolic parameters in all patients with no effects on reproductive hormones, MYO + ALA improved hormonal and metabolic aspects and insulin response to OGTT in all patients. Presence of familial diabetes is a relevant clinical aspect. MYO is less effective when familial diabetes is present, ALA improved only metabolic aspects while MYO + ALA was effective on all PCOS patients independently from familial diabetes.

摘要

多囊卵巢综合征的特征为多种内分泌障碍、胰岛素抵抗和高胰岛素血症。我们的目的是评估肌醇(MYO), 硫辛酸(ALA)以及两者联合应用的效果。此研究为回顾性研究。90例超重/肥胖患者被纳入研究, 患者均确定是否存在一级糖尿病亲属。患者给予MYO(1g/日, 口服), ALA(400 mg/日 口服), MYO(1gr/日)+ALA(400 mg/日)。90名患者中只有76名完成了12周的治疗。在治疗前后评估血浆中LH, FSH, E2(雌二醇), A(雄烯二酮), T(睾酮)水平, 口服葡萄糖耐量试验(OGTT)。所有治疗都显示了特定的积极的效果：在无家族性糖尿病的多囊卵巢综合征(PCOS)患者中, MYO更好的改善了患者的激素水平和OGTT的胰岛素反应, 而ALA改善了所有患者对OGTT的胰岛素反应和代谢参数, 但对激素水平的改善无效, MYO +ALA则改善了所有患者的激素水平、代谢参数以及OGTT的胰岛素反应。家族性糖尿病的存在是一个相关的临床因素。当存在家族性糖尿病时, MYO的疗效较差, ALA仅改善代谢参数, 而MYO+ALA对所有独立于家族性糖尿病的PCOS患者有效。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Alpha-lipoic acid
• diabetes
• hyperinsulinemia
• myo-inositol
• PCOS
• post receptor signal

Disclosure statement

No potential conflict of interest was reported by the authors.