Comparison of triptorelin acetate vs triptorelin pamoate in the treatment of Central precocious puberty (CPP): a retrospective study

Abstract

The aim of this study is to compare the clinical and biochemical outcomes of triptorelin acetate (TPA) versus triptorelin pamoate (TPP) treatment in girls with central precocious puberty. A total of 60 patients with idiopathic CPP were retrospectively recruited. Thirty girls were treated with triptorelin acetate 3.75 mg/month (TPA group) and thirty girls in a second group received triptorelin pamoate 3.75 mg/4 weeks (TPP group). Patient follow-up at 12 and 24 months included GnRH Test at 12 months and baseline LH at 24 months. Patients were monitored with pelvic ultrasound, X-Ray of the hand and wrist and anthropometric evaluations. A total of 60/60 girls showed a good response to both formulations. Significant reductions in basal and LH peaks, estradiol values, breast pubertal stage, progression of bone age and growth velocity rate after 12 months treatment were obtained in both groups, demonstrating the equivalence of the two formulations in regulating the hypothalamic–pituitary-gonadal (HPG) axis. Triptorelin pamoate provided a more effective and significant reduction in LH peak after 12 months in comparison with triptorelin acetate more effective in reducing ovarian volume and endometrial thickness. Both formulations were equivalent, even though the LH peak was significantly lower in girls treated with triptorelin pamoate

摘要

本研究的目的是比较醋酸曲普瑞林（TPA）与双羟萘酸曲普瑞林（TPP）治疗女孩真性性早熟的临床和生化结局。回顾性收集60例特发性CPP患者, 30例女孩接受醋酸曲普瑞林.75 mg/月治疗（TPA组）, 30例女孩接受第二组双羟萘酸曲普瑞林3.75 mg/ 4周治疗（TPP组）。12个月和24个月的患者随访包括12个月的GnRH和24个月的基线LH检测。通过盆腔超声、手和手腕的X线和人体测量评估对患者进行监测。共有60/60名女孩对两种配方的反应都很好。两组治疗12个月后, 基础值和LH峰、雌二醇值、乳腺发育分期、骨龄和生长速度显著降低, 说明两种制剂在调节下丘脑-垂体-性腺（HPG）轴方面是等效的。与醋酸曲普瑞林相比, 双羟萘酸曲普瑞林在12个月后能更有效地降低LH峰值, 并能更有效地减少卵巢体积和子宫内膜厚度。尽管应用双羟萘酸曲普瑞林治疗的女孩LH峰值明显较低, 但两种制剂是等效的。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Central precocious puberty
• triptorelin acetate
• triptorelin pamoate

Disclosure statement

No potential conflict of interest was reported by the authors.