A novel biochemical marker -OKL38- with its apoptotic and antioxidant properties for the development of PCOS and its related clinical implications

Abstract

Aim: To investigate the role of serum OKL38 levels in the development of polycystic ovary syndrome (PCOS) and clinical implications related to PCOS.

Method: PCOS (n = 33) and ovulatory controls (n = 48) were recruited for the study. Anthropometric measurements were recorded, and blood samples for hormonal and biochemical parameters including serum OKL38 levels were obtained. The potential role of OKL38 on the development of PCOS, metabolic syndrome and cardiovascular disease (CVD) were investigated. Framingham risk score (FRS) was used for the determination of CVD risk.

Results: Mean Ferriman–Gallway (FG) score, insulin, low-density lipoprotein (LDL), total cholesterol (TC) levels, and the homeostasis model assessment of insulin resistance index (HOMA-IR) were significantly increased (p < .05) in women with PCOS compared to controls. PCOS group had lower mean OKL38 level compared to controls (p < .0001) and OKL38 was negatively predictive for the diagnosis of PCOS after adjustment of variables that were significantly different between two groups. A negative association between OKL38 and metabolic syndrome in PCOS women was evident after adjustment for age, obesity, and abdominal obesity. OKL38 level was also negatively correlated with body mass index, waist-to-hip-ratio, fat composition, serum TC, LDL, free testosterone levels, FRS, and FG scores.

Conclusion: OKL38 may have a partial role in the etiopathogenesis of PCOS and may protect development of metabolic syndrome and CVD in women with PCOS.

摘要

目的：探讨血清OKL38水平在多囊卵巢综合征(PCOS)发病中的作用及与PCOS相关的临床意义。方法：选择PCOS组(33例)和排卵对照组(48例)进行研究。记录人体测量, 并获取包括血清OKL38水平在内的激素和生化指标的血液样品。探讨OKL38基因在多囊卵巢综合征、代谢综合征和心血管疾病(CVD)发病中的作用。采用Framingham危险度评分(FRS)评价CVD危险性。结果：与对照组相比, PCOS患者的FG评分、胰岛素、低密度脂蛋白(LDL)、总胆固醇(TC)水平和胰岛素抵抗指数(HOMA-IR)均显著升高(P<0.05)。结果：PCOS患者的FG评分、胰岛素、低密度脂蛋白(LDL)、总胆固醇(TC)水平和胰岛素抵抗指数(HOMA-IR)均显著高于对照组(P<0.05)。PCOS组的平均OKL38水平低于对照组(P<.0001), 在调整了两组之间有显著差异的变量后, OKL38对PCOS的诊断有阴性预测作用。在对年龄、肥胖和腹型肥胖进行调整后, OKL38与多囊卵巢综合征妇女的代谢综合征呈明显的负相关。OKL38水平与体重指数、腰臀比、脂肪组分、血清TC、LDL、游离睾酮水平、FRS和FG评分呈负相关。结论：OKL38可能在多囊卵巢综合征的发病机制中起部分作用, 对多囊卵巢综合征患者代谢综合征和心血管疾病的发生有一定的保护作用。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• PCOS
• OKL38
• metabolic syndrome
• cardiovascular disease risk

Acknowledgements

The authors would like to thank to residents and personnel at the Department of Obstetrics and Gynecology of Kanuni Sultan Suleyman Training Hospital for obtaining the samples. Special thanks to participants for their patience and kindness.

Disclosure statement

No potential conflict of interest was reported by the authors.