Effect of d-chiro-inositol and alpha-lipoic acid combination on COH outcomes in overweight/obese PCOS women

Abstract

Insulin resistance (IR) plays a central role in the onset of polycystic ovary syndrome (PCOS). Insulin so insulin-sensitizing like inositols have been proposed as first line therapy. Among them d-chiro-inositol (DCI) seems to improve glucose metabolism and to increase ovulation frequency. Other studies have demonstrated that alpha-lipoic acid (ALA), with its antioxidant role, can also improve endocrine and metabolic profile of PCOS patients especially with familial diabetes. This a retrospective observational study with the aim to evaluate possible advantages of an integrative preparation combining DCI 500 mg and ALA 300 mg in overweight/obese PCOS patients with or without diabetic relatives who underwent IVF. Twenty PCOS patients who were taking the integrative preparation underwent controlled ovarian hyperstimulation in our center. The group with diabetic relatives tended to have a lower dose of gonadotropin, shorter stimulation days, higher number of MII oocytes, and higher number of fertilized oocytes. A combined regimen of DCI and ALA could be an interesting strategy in overweight PCOS patients with familial diabetes underwent ART.

摘要

胰岛素抵抗（IR）在多囊卵巢综合征（PCOS）的发病中起着重要作用。胰岛素以及胰岛素增敏样肌醇被提议作为一线治疗。其中手性肌醇（DCI）似乎可以改善葡萄糖代谢, 增加排卵频率。其他研究表明, α-硫辛酸（ALA）具有抗氧化作用, 能改善多囊卵巢综合征患者的内分泌和代谢状况, 尤其是家族性糖尿病患者。这是一项回顾性研究, 目的旨在评估联合应用DCI 500mg和ALA 300mg对进行IVF的超重/肥胖PCOS患者（有或没有糖尿病亲属）预处理的可能优势。本中心接受控制性超排卵治疗的20例多囊卵巢综合征患者接受了综合预处理。有糖尿病家族史组有促性腺激素剂量较低, 刺激日数较短, MII卵母细胞数较多, 受精卵数较多的趋势。DCI和ALA联合方案可能是超重多囊卵巢综合征合并家族性糖尿病患者接受ART治疗的一个可行的策略。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Polycystic ovary syndrome
• PCOS
• inositol
• d-chiro-inositol
• infertility
• IVF

Disclosure statement

All authors declare that they have no conflicts of interest.