Assisted oocyte activation with calcium ionophore 44 hours after intracytoplasmic sperm injection resulting in successful pregnancy

Abstract

Assisted Oocyte Activation (AOA) with Calcium Ionophore, is possible to manually activate the oocytes and cure globozoospermia, thus leading to successful pregnancy in 1 h after ICSI. But in this case, we report a case that 44 h after ICSI, the arrest zygotes assisted oocyte activation with calcium ionophore, obtained clinical pregnancy and live birth. Accordingly, AOA may provide us with an immediate treatment for embryonic arrest in the future.

摘要

采用钙离子载体辅助卵母细胞激活（AOA）, 可能可以人工激活卵母细胞, 治愈圆头精子症, 从而在ICSI后1小时内成功妊娠。但在此例中, 我们报道了一例ICSI后44h, 受精卵被钙离子载体辅助激活, 获得临床妊娠和活产。因此, AOA可能会在未来为我们提供一种立即治疗胚胎停滞的方法。

Keywords:

• Assisted Oocyte Activation
• Embryonic Arrest
• Intracytoplasmic Sperm Injection
• 44 Hours

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the Natural Science Foundation of Zhejiang Province, China (C20170007), Natural Science Foundation of Zhejiang Province, China (LQ17H040003) and Wenzhou City Key Innovation Team of Reproductive Genetics Grant, Zhejiang, China (C20170007).