Neudesin: a neuropeptide hormone decreased in subjects with polycystic ovary syndrome

Abstract

Neudesin is a neuropeptide hormone involves in female reproduction system via promoting effects of progesterone. Polycystic ovary syndrome (PCOS) is a metabolic and reproductive disorder associated with hypothalamic-pituitary-ovarian axis abnormalities and impaired negative feedback mechanism of progesterone upon gonadotropin-releasing hormone secretion. Our aims were to discover whether neudesin levels were altered in PCOS women comparing to controls and to determine the link of neudesin with hormonal-metabolic parameters in PCOS women. The current research was designed as a case-control study. Sixty-eight subjects with PCOS and 67 age- and body mass index (BMI)-matched subjects as controls were enrolled into the study. Circulating neudesin levels were measured by ELISA. Neudesin levels were significantly lower in PCOS subjects compared to controls (4.07 ± 1.22 vs. 6.02 ± 2.07 ng/ml, p < .001). Neudesin exhibited an inversely independent link with luteinizing hormone, free-androgen index, and BMI whereas it showed a positively independent link with progesterone in women with PCOS. Logistic regression analysis revealed that decreased neudesin levels were parallel with increased risk of having PCOS. Decreased neudesin levels were associated with hormonal disturbances in PCOS women, suggesting that neudesin may play a role in pathophysiology of PCOS.

Chinese abstract

Neudesin是一种神经肽激素, 通过孕酮的促进作用参与女性生殖系统。多囊卵巢综合征（PCOS）是一种伴有下丘脑-垂体-卵巢轴异常和孕酮对促性腺释放激素分泌负反馈机制受损的代谢生殖疾病。我们的目标是研究多囊卵巢综合征患者与对照组相比, 体内的Neudesin水平是否发生了改变, 并确定多囊卵巢综合征患者体内Neudesin与激素代谢关系的参数。本研究为病例对照研究。68名多囊卵巢综合征患者和67名年龄和BMI匹配的受试者作为对照组纳入研究。ELISA法测定体内循环的Neudesin水平。PCOS患者的Neudesin水平明显低于对照组(4.07±1.22 vs. 6.02±2.07ng/ml, p<.001)。Neudesin与黄体生成素、游离雄激素指数和BMI呈负相关, 而与PCOS患者的黄体酮呈正相关。Logistic回归分析显示, Neudesin水平降低与多囊卵巢综合征风险的增加是平行的。Neudesin水平的降低与PCOS女性的激素紊乱相关, 提示Neudesin可能在PCOS的病理生理学中发挥重要作用。

Keywords:

• Polycystic ovary syndrome
• neudesin
• progesterone
• body mass index
• hyperandrogenism

Author contributions

G.B., O.F., A.G, I.D., B.A. and M.C. participated in study design and B.A., G.B. and O.F. performed ELISA. G.B., O.F., A.G, I.D., B.A. and M.C participated in study design, analyzed the data, wrote, reviewed and edited the manuscript. I.D., A.G. and M.C. provided serum samples and contributed to discussions of data interpretation. All authors reviewed and edited the manuscript. M.C. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Compliance with ethical standards

The subjects gave their oral and written informed consent before their inclusion in the study. The study adhered strictly to the principles of the Declaration of Helsinki as revised in 2008.

Disclosure statement

No potential conflict of interest was reported by the author(s).