Alpha-lipoic acid supplementation effects on serum values of some oxidative stress biomarkers in women with gestational diabetes

Abstract

Aims

Alpha-lipoic acid (ALA) is a unique antioxidant that can eradicate different kinds of free radicals. The current trial was designed to investigate the effects of ALA supplementation on some oxidative stress biomarkers in women with GDM.

Materials and methods

Sixty women with GDM at 24–28 weeks of pregnancy were selected and then they were divided into the drug (n = 30) received ALA 300 mg/day for 8 weeks and the placebo (n = 30) groups. Serum values of fasting blood sugar (FBS), thiol groups, glutathione, catalase, total antioxidant capacity (TAC), total oxidant status (TOS) and malondialdehyde (MDA) were measured. Values of the oxidative stress index (OSI), the MDA/TAC ratio and total antioxidant gap (TAG) were calculated.

Results

After the intervention values of FBS (p = .001), TAC (p < .001), OSI (p = .003), TAG (p = .001) and catalase (p < .001) were improved significantly in the drug group. Values of TOS (p = .070) and glutathione (p = .088) were improved marginally in the drug group.

Conclusions

The current study showed that ALA supplementation at a dosage of 300 mg/day in women with GDM had improving effects on maternal circulating values of FBS, TAC, OSI, TAG, TOS, glutathione and catalase.

补充α-硫辛酸对妊娠期糖尿病女性某些氧化应激生物标志物血清值的影响 摘要

目的：α-硫辛酸（ALA）是一种独特的抗氧化剂, 可以清除各种自由基。本试验旨在研究补充ALA对妊娠期糖尿病（GDM）女性某些氧化应激生物标志物的影响。

材料和方法：纳入60名妊娠24-28周患有GDM女性, 然后将她们分为药物组（n=30）（应用ALA 300 mg/天8周）和安慰剂组（n=30）。测定空腹血糖（FBS）、巯基、谷胱甘肽、过氧化氢酶、总抗氧化能力（TAC）、总氧化状态（TOS）和丙二醛（MDA）的血清值。计算氧化应激指数（OSI）、MDA/TAC比值和总抗氧化间隙（TAG）。

结果：进行干预后药物组FBS（p=.001）、TAC（p<0.001）、OSI（p=.003）、TAG（p=.001）和过氧化氢酶（p<0.001）值显著改善。药物组TOS（p=.070）和谷胱甘肽（p=.088）值稍有改善。

结论：目前研究表明, GDM女性补充300 mg/d剂量的ALA可改善母体循环FBS、TAC、OSI、TAG、TOS、谷胱甘肽和过氧化氢酶值

Keywords:

• Gestational diabetes
• pregnancy
• lipoic acid
• oxidative stress
• antioxidants

Disclosure statement

The authors have no conflicts of interest to declare.

Additional information

Funding

The authors gratefully acknowledge the Research Council of Arak University of Medical Sciences [Grant Number: 3093] for the financial support and Reserch Development Center of Kamali hospital in Alborz University of Medical Sciences. This work was performed in partial fulfillment of the requirements for M.Sc. degree of Masoome Mandani, in the School of Medicine, Arak University of Medical Sciences, Arak, Iran.