Strategy to improve the female fertility in the general gynecologist's office: use of a nutritional supplement based on myo-inositol/D-chiro-inositol and antioxidants

Abstract

Subfertility is more than a quality-of-life problem as it has a substantial negative public health impact. Polycystic ovary syndrome (PCOS) is one of the most common causes of subfertility, affecting one out of 10 women in reproductive age. Among PCOS women undergoing assisted reproductive technology, treatment based on myo-inositol and high doses of D-chiro-inositol has been shown to increase pregnancy rate and number of live births, reduce ovarian hyperstimulation syndrome and improve oocyte quality. A preparation based on myo-inositol and high doses of D-chiro-inositol, together with antioxidants, vitamins, and minerals, could have beneficial effects and be an optimal strategy to improve female fertility in the general gynecologist's office. The aim of this review is to highlight the role of inositol and its isomers in improving fertility of women with PCOS.

普通妇科诊所提高女性生育能力的策略：应用基于肌肌醇/D-手性肌醇和抗氧化剂的营养补充剂 摘要

生育力低下不仅仅是一个生活质量问题, 因为它对公共健康有着重大的负面影响。多囊卵巢综合征（PCOS）是导致生育力低下的最常见原因之一, 每10名育龄期女性中就有一人患病。在接受辅助生殖技术治疗的PCOS患者中, 基于肌醇和大剂量D-手性肌醇的治疗已被证实能提高妊娠率和活产数, 减少卵巢过度刺激综合征, 并改善卵泡质量。一种基于肌醇和高剂量D-手性肌醇, 以及抗氧化剂、维生素和矿物质的制剂, 可能会产生有益的疗效, 并成为普通妇科诊所改善女性生育力的最佳策略。本综述目的是强调肌醇及其异构体在改善PCOS女性生育力中的作用。

Keywords:

• Subfertility
• polycystic ovary syndrome
• myo-inositol
• D-chiro-inositol
• antioxidants

Disclosure statement

Mendoza, N. participated in the clinical study described in the manuscript, funded by Procare Health Spain; Losa, F. participated in the clinical study described in the manuscript, funded by Procare Health Spain; Palacios, S. has no conflict of interest.