Selenium supplementation for polycystic ovary syndrome: a meta-analysis of randomized controlled trials

Abstract

Introduction: The efficacy of selenium supplementation was elusive for polycystic ovary syndrome. This meta-analysis aimed to explore the efficacy of selenium supplementation for polycystic ovary syndrome. Methods: PubMed, EMbase, Web of science, EBSCO, Cochrane library database, CNKI, Chongqing VIP database and Wanfang databases have been searched through July 2022 and we included randomized controlled trials (RCTs) reporting the effect of selenium supplementation versus placebo in patients with polycystic ovary syndrome. Results: Five RCTs were included in the meta-analysis. Compared with placebo group for polycystic ovary syndrome, selenium supplementation was associated with significantly reduced total testosterone (SMD=-0.42; 95% CI=-0.78 to −0.06; p = 0.02) and cholesterol (SMD=-0.71; 95% CI=-1.41 to −0.02; p = 0.04), but revealed no remarkable influence on SHBG (SMD=-0.52; 95% CI=-1.29 to 0.25; p = 0.19), triglyceride (SMD=-1.45; 95% CI=-3.62 to 0.73; p = 0.19), LDL (SMD=-0.17; 95% CI=-0.72 to 0.37; p = 0.53), FPG (SMD=-0.95; 95% CI=-3.72 to 1.82; p = 0.50) or HOMA-IR (SMD=-0.51; 95% CI=-3.79 to 2.77; p = 0.76). Conclusions: Selenium supplementation may be able to improve the metabolic response for polycystic ovary syndrome, and this finding should be interpreted with caution.

摘要

前言

补硒对多囊卵巢综合征的疗效难以捉摸。本meta分析旨在探讨补硒治疗多囊卵巢综合征的疗效。

方法

检索了PubMed、EMbase、Web of science、EBSCO、Cochrane图书馆数据库、CNKI、重庆VIP数据库和万方数据库, 检索至2022年7月, 我们纳入了报告补硒与安慰剂治疗多囊卵巢综合征患者效果的随机对照试验（RCTs）。

结果

5项RCTs纳入此meta分析。相比于安慰剂治疗多囊卵巢综合征, 补硒与血清总睾酮（SMD=-0.42; 95% CI=-0.78 to −0.06; p=0.02）和胆固醇（SMD=-0.71; 95% CI=-1.41 to −0.02; p=0.04）的显著降低有关, 但对SHBG（SMD=-0.52; 95% CI=-1.29 to 0.25; p=0.19）、甘油三酯（SMD=-1.45; 95% CI=-3.62 to 0.73; p=0.19）、LDL（SMD=-0.17; 95% CI=-0.72 to 0.37; p=0.53）、FPG（SMD=-0.95; 95% CI =-3.72 to 1.82; p=0.50）或HOMA-IR（SMD=-0.51; 95% CI =-3.79 to 2.77; p=0.76）无显著影响。

结论

补硒可能能够改善多囊卵巢综合征的代谢反应, 这一发现应谨慎解释。

Keywords:

• Selenium supplementation
• testosterone
• polycystic ovary syndrome
• randomized controlled trials

关键词:

• 补硒
• 睾酮
• 多囊卵巢综合征
• 随机对照试验

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

The author(s) reported there is no funding associated with the work featured in this article.