The association between serum fatty acids and pregnancy in PCOS women undergoing ovulation induction

Abstract

Background

Long-term dietary fat intake is thought to affect metabolism and pregnancy of polycystic ovary syndrome (PCOS) patients, and the type of fatty acids one consumes plays an important role. Previous studies mostly used questionnaires to analyze the type and proportion of fatty acids.

Methods

This prospective study included 91 PCOS patients. Serum fatty acids were measured by the gas chromatograph-mass spectrometry method before ovulation induction. We compared the fatty acids between the pregnancy group and the nonpregnancy group and explored the influence of the fatty acids on live births and pregnancy loss.

Results

Nervonic acid was lower in the pregnancy group than in the nonpregnancy group (0.25% vs. 0.30%, p = .017). The following trans-fatty acids were significantly lower in the pregnancy group than in the nonpregnancy group: trans-10-heptadecenoic acid, trans-vaccenic acid, trans-11-eicosenoic acid, and brassidic acid. The level of polyunsaturated fatty acids in the live birth group was significantly higher than the pregnancy loss group (16.95% vs. 15.10%, p = .039). Among individual PUFAs, the levels of linoleic acid (p = .043), docosapentaenoic acid (p = .024), alpha-linolenic acid (p = .042), and eicosapentaenoic acid (p = .035) were higher in the live birth group than in the pregnancy loss group. After adjusting for infertility duration, age, and body mass index, our findings suggested an inverse association between pregnancy and nervonic acid, trans-10-heptadecenoic acid, trans-vaccenic acid, trans-11-eicosenoic acid, and brassidic acid and pregnancy.

Conclusions

Our findings indicate that polyunsaturated fatty acids are associated with live birth in PCOS patients. Serum trans-fatty acids and nervonic acid might be risk factors for nonpregnancy. The mechanism of the influence of different fatty acids on pregnancy and live birth merits further exploration.

摘要

背景

多囊卵巢综合征(PCOS)患者长期的膳食脂肪摄入被认为影响其代谢和妊娠, 其中所摄入的脂肪酸类型起着重要作用。以往的研究大多采用问卷调查的方式来分析脂肪酸的种类和比例。

方法

对91例PCOS患者进行前瞻性研究。诱导排卵前用气相色谱-质谱联用法测定血清脂肪酸含量。我们比较了妊娠组和未妊娠组的脂肪酸, 并探讨了脂肪酸对活产和妊娠丢失的影响。

结果

妊娠组神经酸低于非妊娠组(0.25% vs. 0.30%, p = .017)。以下反式脂肪酸（反式-10-十七碳烯酸、反式-疫苗酸、反式-11-二十碳烯酸和油菜酸）在妊娠组显著低于非妊娠组。活产组多不饱和脂肪酸水平显著高于未妊娠组(16.95% vs. 15.10%, p = .039)。在PUFAs个体中, 活产组的亚油酸(p = .043)、十二碳五烯酸(p = .024)、-亚麻酸(p = .042)和二十碳五烯酸(p = .035)水平高于妊娠丢失组。在调整不孕症持续时间、年龄和体重指数后, 我们的研究结果表明, 怀孕与神经酸、反式10-十七烯酸、反式疫苗酸、反式11-二十烯酸和油菜酸之间存在负相关关系。

结论

我们的研究结果表明多不饱和脂肪酸与多囊卵巢综合征患者的活产有关。血清反式脂肪酸和神经酸可能是未妊娠的危险因素。不同脂肪酸对妊娠和活产的影响机制值得进一步探讨。

Keywords:

• Polycystic ovary syndrome
• serum fatty acids
• ovulation induction
• pregnancy
• live birth

关键词:

• 多囊卵巢综合征
• 血清脂肪酸
• 促排卵
• 怀孕
• 活产

Acknowledgment

Not applicable.

Ethics approval and consent to participate

This study was approved by Tianjin Medical University General Hospital.

Author’s contributions

Xueru Song and Ye Tian conceived and designed the experiments. Mingyue Li and Ye Tian collected the samples, performed the experiments and analyzed the data. Yonghuan Lv, Yanping Xu, Xiaohong Bai, Huijuan Zhang and Yanxia Wang collected the samples. All authors approved the final article.

Data availability

Data available on request from the corresponding author

Conflict of interest

The authors declare no competing interests

Consent for publication

Not applicable.

Additional information

Funding

This work was supported by grants from National Natural Science Foundation of China (82171625 to Y.T., 81701410 to Y.T.), Beijing-Tianjin-Hebei Basic Research Cooperation Program (19JCZDJC65000Z to X.S., 19JCZDJC65000 to X.S.) and Natural Science Foundation of Tianjin (20JCQNJC00470 to Y.T.). Meanwhile, this work was funded by Tianjin Key Medical Discipline (Specialty) Construction Project (TJYXZDXK-031A).