Coronary heart disease and HRT in France: MISSION study prospective phase results

Abstract

Objective. To determine the morbidity incidence associated with Hormone Replacement Therapy (HRTs) in postmenopausal women. This paper presents the results concerning the incidence of coronary heart disease (CHD).

Design. MISSION study started on 5 January 2004, the cutoff for data collection was June 2006 (follow-up no. 1). ‘Exposed group’: postmenopausal women currently on HRT, commonly prescribed in France or stopped ≤5 years previously. ‘Unexposed group’: never received HRT or stopped >5 years previously.

Results. Data were available for 4949 patients (without CHD at the beginning of the follow-up): 2693 Exposed group and 2256 Unexposed group. The incidence during follow-up no. 1 of postmenopausal CHD was not significantly different in the Exposed group (0.11%) compared with the Unexposed group (0.13%). In the Exposed group the time between start of HRT and menopause was 2.93 ± 4.46 years in those who experienced CHD and 1.53 ± 3.20 years in those who had no incidence of CHD (p = 0.3).

Conclusion. In the MISSION cohort, no increased risk of CHD was found in the Exposed group compared with the Unexposed group

Keywords:

• Hormone replacement therapy
• coronary heart disease
• menopause
• epidemiology
• incidence
• French cohort study