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Platelets Volume 20, 2009 - Issue 1
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Case Report

Acute profound thrombocytopenia with second exposure to eptifibatide associated with a strong antibody reaction

Shariff Attaya Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio
,
Yogendra Kanthi Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio
,
Richard Aster Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin
&
Keith McCrae Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OhioCorrespondence[email protected]
Pages 64-67 | Received 05 Oct 2008, Accepted 28 Oct 2008, Published online: 07 Jul 2009
 
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Abstract

We present a case of eptifibatide-induced acute profound thrombocytopenia in a 64-year-old male receiving eptifibatide for the second time during percutaneous coronary intervention. Although rare, short and self-limited episodes of acute and profound thrombocytopenia have been associated with eptifibatide exposure. The thrombocytopenia is thought to be immune mediated, and assays are available to test for eptifibatide-induced platelet antibodies.

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