Omalizumab treatment in a 12 year-old girl with chronic spontaneous urticaria

Abstract

Background: Omalizumab is a recombinant humanized IgG monoclonal antibody, which binds the Fc region of free IgE prevent its binding to its high-affinity receptor (FcεR1) on mast cells and basophils. Omalizumab was approved as add-on therapy for moderate-to-severe persistent allergic asthma and for patients with chronic spontaneous urticaria resistant to antihistamine treatment.

Patient and results: This article reports effective and safe treatment of a 12 years old girl with add-on omalizumab. On an initial dose of omalizumab of 300 mg once every 4 weeks, the patient experienced resolution of symptoms to a degree that exceeded the effect of previous treatments.

Conclusion: Convincing evidence in support of the efficacy and safety of Omalizumab in the treatment of CSU in adolescent has accumulated over the past few years.

KEYWORDS:

• Chronic urticaria
• IgE
• omalizumab
• antihistamines

Acknowledgment

Medical writing assistance of this paper was provided by Laura Brogelli, on behalf of Content Ed Net; this assistance was funded by Novartis.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This supplement was funded by Novartis.