![Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5944/TOC-Subject-Sample-2021-Medicine-Dentistry-Nursing-Allied-Health.jpg"})
Abstract
Purpose: Caveolae are non-clathrin, flask-shaped invaginations of the plasma membrane. Caveolin-1 is an essential constituent of caveolae and as such acts as a regulator of caveolae-dependent lipid trafficking and endocytosis. Caveolin-1 interacts with a variety of cellular proteins and regulates cell-signaling events.
Caveolin-1 appears to act as a tumor suppressor protein at early stages of cancer progression. However, a growing body of evidence indicates that caveolin-1 is up-regulated in several multidrug-resistant and metastatic cancer cell lines and human tumor specimens. Furthermore, caveolin-1 levels are positively correlated with tumor stage and grade in numerous cancer types.
Conclusion: The available experimental data support the tumor-promoting role of caveolin-1 in advanced-stage cancer.
| Abbreviations | ||
| ABCB1 | = | ATP-binding cassette, sub-family B, member 1; |
| CAV1 | = | caveolin-1; |
| Crk-I | = | CT10-regulated kinase-I; |
| EGF | = | epidermal growth factor; |
| eNOS | = | endothelial nitric oxide synthase; |
| Erk1/2 | = | extracellular signal-regulated kinase 1/2; |
| EWS | = | Ewing's sarcomas; |
| FRT | = | Fisher rat thyroid cells; |
| GlcCer | = | glucosylceramide; |
| HUVEC | = | human umbilical vein endothelial cells; |
| IGF-I | = | insulin-like growth factor I; |
| MAPK | = | mitogen-activated protein kinase; |
| MDR | = | multidrug resistance; |
| MMP | = | matrix metallopeptidase; |
| MRP1 | = | multidrug resistance-associated protein-1; |
| NSCLC | = | non-small cell lung carcinoma; |
| P-gp | = | P-glycoprotein; |
| PI3K | = | Phosphoinositide 3-kinase; |
| PNI | = | perineural invasion; |
| Shc | = | Src homology domain containing; |
| siRNA | = | short interfering RNA; |
| TRAMP | = | transgenic adenocarcinoma of mouse prostate; |
| PyMT | = | Polyoma virus middle T |
| Abbreviations | ||
| ABCB1 | = | ATP-binding cassette, sub-family B, member 1; |
| CAV1 | = | caveolin-1; |
| Crk-I | = | CT10-regulated kinase-I; |
| EGF | = | epidermal growth factor; |
| eNOS | = | endothelial nitric oxide synthase; |
| Erk1/2 | = | extracellular signal-regulated kinase 1/2; |
| EWS | = | Ewing's sarcomas; |
| FRT | = | Fisher rat thyroid cells; |
| GlcCer | = | glucosylceramide; |
| HUVEC | = | human umbilical vein endothelial cells; |
| IGF-I | = | insulin-like growth factor I; |
| MAPK | = | mitogen-activated protein kinase; |
| MDR | = | multidrug resistance; |
| MMP | = | matrix metallopeptidase; |
| MRP1 | = | multidrug resistance-associated protein-1; |
| NSCLC | = | non-small cell lung carcinoma; |
| P-gp | = | P-glycoprotein; |
| PI3K | = | Phosphoinositide 3-kinase; |
| PNI | = | perineural invasion; |
| Shc | = | Src homology domain containing; |
| siRNA | = | short interfering RNA; |
| TRAMP | = | transgenic adenocarcinoma of mouse prostate; |
| PyMT | = | Polyoma virus middle T |
| Abbreviations | ||
| ABCB1: | = | ATP-binding cassette, sub-family B, member 1; |
| CAV1: | = | caveolin-1; |
| Crk-I: | = | CT10-regulated kinase-I; |
| EGF: | = | epidermal growth factor; |
| eNOS: | = | endothelial nitric oxide synthase; |
| Erk1/2: | = | extracellular signal-regulated kinase 1/2; |
| EWS: | = | Ewing's sarcomas; |
| FRT: | = | Fisher rat thyroid cells; |
| GlcCer: | = | glucosylceramide; |
| HUVEC: | = | human umbilical vein endothelial cells; |
| IGF-I: | = | insulin-like growth factor I; |
| MAPK: | = | mitogen-activated protein kinase; |
| MDR: | = | multidrug resistance; |
| MMP: | = | matrix metallopeptidase; |
| MRP1: | = | multidrug resistance-associated protein-1; |
| NSCLC: | = | non-small cell lung carcinoma; |
| P-gp: | = | P-glycoprotein; |
| PI3K: | = | Phosphoinositide 3-kinase; |
| PNI: | = | perineural invasion; |
| Shc: | = | Src homology domain containing; |
| siRNA: | = | short interfering RNA; |
| TRAMP: | = | transgenic adenocarcinoma of mouse prostate; |
| PyMT: | = | Polyoma virus middle T |
Notes
This paper was presented at the Workshop on Radiation and Multidrug Resistance Mediated by the Tumor-Microenvironment, guest edited by Dr. Cordes and Dr. Mary Helen Barcellos-Hoff.