Abstract
Purpose: The possibility of a large-scale acute radiation exposure necessitates the development of new methods that could provide a rapid assessment of the doses received by individuals using high-throughput technologies. There is also a great interest in developing new biomarkers of dose exposure, which could be used in large molecular epidemiological studies in order to correlate estimated doses received and health effects. The goal of this review was to summarize current literature focused on biological dosimetry, namely radiation-responsive biomarkers.
Methods: The studies involved in this review were thoroughly selected according to the determined criteria and PRISMA guidelines.
Results: We described briefly recent advances in radiation genomics and metabolomics, giving particular emphasis to proteomic analysis. The majority of studies were performed on animal models (rats, mice, and non-human primates). They have provided much beneficial information, but the most relevant tests have been done on human (oncological) patients. By inspecting the radiaiton biodosimetry literate of the last 10 years, we identified a panel of candidate markers for each –omic approach involved.
Conslusions: We reviewed different methodological approaches and various biological materials, which can be exploited for dose-effect prediction. The protein biomarkers from human plasma are ideal for this specific purpose. From a plethora of candidate markers, FDXR is a very promising transcriptomic candidate, and importantly this biomarker was also confirmed by some studies at protein level in humans.
Acknowledgments
The authors thank Dr. Ian McColl for proof reading the manuscript.
Disclosure statement
No potential conflict of interest was reported by the authors.
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Notes on contributors
Gabriela Kultova
Gabriela Kultova, MSc, is a PhD student at the Department of Biology, Faculty of Science, University of Hradec Kralove, Hradec, Kralove, Czech Republic.
Ales Tichy
Ales Tichy, PharmD, PhD, is an Associate Professor (Docent) of Radiobiology at the Department of Radiobiology, Faculty of Military Health Sciences, Hradec Kralove, University of Defense, Brno, Czech Republic.
Helena Rehulkova
Helena Rehulkova, PhD. is a Postdoc at the Department of Radiobiology, Faculty of Military Health Sciences, Hradec Kralove, University of Defense, Brno, Czech Republic.
Alena Myslivcova-Fucikova
Alena Myslivcova-Fucikova, PhD. is a Postdoc at the Department of Radiobiology, Faculty of Militatry Health Sciences, Hradec Kralove, University of Defense, Brno, Czech Republic.