In-vivo and in vitro assessments of the radioprotective potential natural and chemical compounds: a review

Abstract

Purpose

The study of the radioactive role of natural and chemical substances on human and animal studies has been the subject of research by some researchers. Therefore, the review of some of the past and current studies conducted in this field, can provide helpful information to elucidate of the importance of radioprotective components in reducing radiation exposure side effects.

Methods

The authors search for keywords including In vitro, In vivo, Radioprotective, Ionizing radiation, and Vitamin in ScienceDirect, Scopus, Pubmed, and Google Scholar databases to access previously published articles and search for more reference articles on the role of radioprotective materials from natural and chemical compounds.

Results

Radiation exposure can produce reactive oxygen species (ROS) in the body, however most of which are eliminated by the body’s natural mechanisms, but when the body’s antioxidant systems do not have enough ability to neutralize free radicals, oxidative stress occurs, which causes damage to DNA and body tissues. Therefore, it is necessary use of alternative substances that reduce and inhibit free radicals.

Conclusion

In general, recommended that antioxidant component(s) can be protect tissue damages in humans or animals, due to the their ability to scavenge free radicals generated by ionizing radiation.

Keywords:

• Antioxidants
• ionizing radiation
• in vitro
• in vivo
• radioprotective

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Notes on contributors

Anis Javadi

Anis Javadi is in Department of Pharmacognosy and Pharmaceutical Biotechnology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran

Mohammad Reza Nikhbakht

Mohammad Reza Nikhbakht is in Department of Physiology and Pharmacology, School of Medicine Medicinal Plants Research Center Yasuj University of Medical Sciences

Javad Ghasemian Yadegari

Javad Ghasemian Yadegari is in Department of Pharmacognosy and Pharmaceutical Biotechnology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran.

Auob Rustamzadeh

Auob Rustamzadeh is in Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Mohsen Mohammadi

Mohsen Mohammadi is in Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

Alireza Shirazinejad

Alireza Shirazinejad is in Department of Food Science and Technology, Sarvestan Branch, Islamic Azad University, Sarvestan, Iran

Saleh Azadbakht

Saleh Azadbakht is in Department of Internal Medicine, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

Zahra Abdi

Zahra Abdi is in Department of Medical Biotechnology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran