Air pollution and molecular changes in age-related diseases

ABSTRACT

Assessment of the impact that air contaminants have on health is difficult as this is a complex mixture of substances that varies depending on the time and place. There are many studies on the association between air pollution and increased morbidity and mortality. Before the effect of polluted air is manifested at the level of the organs, an impact can be observed at the molecular level. These include some new biomarkers, like a shortening of the mean telomere length in DNA, dysregulation of gene expression caused by microRNA levels or a variation in the copy number of mitochondrial DNA. These changes may predispose individuals to premature development of age-related diseases and consequently to shortening of life. The common attribute, shared by changes at the molecular level and the development of diseases, is the presence of oxidative stress.

KEYWORDS:

• Outdoor air pollution
• particulate matter
• exposure
• oxidative stress
• aging

Acknowledgments

This work was supported by the European Regional Development Fund under Grant Healthy Aging in Industrial Environment HAIE CZ.02.1.01/0.0/0.0/16_019/0000798.

Additional information

Funding

This work was supported by the European Regional Development Fund under Grant Healthy Aging in Industrial Environment HAIE (CZ.02.1.01/0.0/0.0/16_019/0000798).