Lipoic Acid Confers Protection Against Oxidative Injury in Non-neuronal and Neuronal Tissue

Abstract

In the past decade or so, a convincing link between oxidative stress and degenerative conditions has been made and with the knowledge that oxidative changes may actually trigger deterioration in cell function, a great deal of energy has focussed on identifying agents which may have possible therapeutic value in combating oxidative changes. One agent which has received attention, because of its powerful antioxidative effects, particularly in neuronal tissue, is lipoic acid.

Keywords:

• Antioxidants
• Reactive oxygen species
• Age
• Neurodegeneration
• Hippocampus
• LTP