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Abstract
Two new triterpenes mayteneri A (1), mayteneri B (2), and seven known compounds (3-9) were isolated from stems of Maytenus hookeri Loes. The chemical structures of compounds 1 and 2 were established by 1D, 2D NMR, HRESIMS analysis, and calculating electronic circular dichroism (ECD). The structures of known compounds 3-9 were determined by comparison of their spectral with those reported. Compounds 4-7 showed significant inhibitory activity for NLRP3 inflammasome, with the IC50 values of 2.36–3.44 μM.
Acknowledgements
Authors thank Advanced Analysis and Measurement Center of Yunnan University for the sample testing service.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Funding
This work was financially supported by the National Natural Science Foundation of China (22167021, 82260682), the Applied Basic Research Foundation of Yunnan Province (202101AT070195, 202101AT070864, 2018FY001 and 2018FA048), Program for Changjiang Scholars and Innovative Research Team in University (IRT_17R94), the Yun Ling Scholar Project to Wei-Lie Xiao, Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform (2022YKZY001), the Graduate Scientific Research and Innovation Fund Project of Yunnan University (KC-22222246). Authors thank Advanced Analysis and Measurement Center of Yunnan University for the sample testing service.