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Abstract
Cyclopenta[c]phenanthrene (CP[c]Ph) is a PAH member that shows similarities to bay-and fjord region possessing PAHs. On the basis of X-ray measurements it was found that the molecule of this hydrocarbon is planar. In this case, intramolecular strains caused by repulsion between protons in the pseudo fjord-region are balanced by both the shortening of some bonds which acquire more double bond character, and by the enlargement of exocyclic angles within the pseudo fjord-region. The activity of CP[c]Ph was investigated in vivo in rainbow trout, Oncorhynchus mykiss. The CYP1A mRNA levels following 48h-treatment with CP[c]Ph or benzo[a]pyrene (B[a]P; positive control) were determined and compared with incidences of clastogenic changes observed in the peripheral blood erythrocytes. We have found that the ability to induce CYP1A by these PAH compounds is positively correlated with the incidences of clastogenic changes in rainbow trout erythrocytes.
We thank Professor Miroslaw Luczyński, Department of Environmental Biotechnology, UWM in Olsztyn, and two anonymous reviewers for helpful comments on the paper; M.Sc. Elźbieta Ziomek for the collection and preparation of the blood smears; and M.Sc. Renata Lewandowska for her excellent technical assistance. This work was supported by the Polish Committee for Scientific Research, Project No. 2 P06D 001 29.
Notes
a NCBI gene bank accession ID, as confirmed by BLAST sequence analysis.
b This study.
∗ P < 0.05;
∗∗ P < 0.01.
∗ Denotes a significant correlation at p < 0.0125.