LysR-type transcriptional regulators: state of the art

Abstract

The LysR-type transcriptional regulators (LTTRs) are DNA-binding proteins present in bacteria, archaea, and in algae. Knowledge about their distribution, abundance, evolution, structural organization, transcriptional regulation, fundamental roles in free life, pathogenesis, and bacteria–plant interaction has been generated. This review focuses on these aspects and provides a current picture of LTTR biology.

Keywords:

• DNA-binding proteins
• bacteria
• archaea
• transcriptional regulation
• virulence

Acknowledgements

We would like to thank M. Fernández-Mora, F. J. Santana, L. Perezgasga, A. Vazquez, and J. E. Rebollar-Flores for technical help in LTTR studies. We also thank E. Calva and M. Dunn for stimulating discussions and critical reading. We thank biorender.com because figures were created with BioRender software.

Disclosure statement

The authors declare that they have no conflicts of interest.

Additional information

Funding

This work was supported by grants from the Dirección General de Asuntos Del Personal Académico, DGAPA/UNAM (IN203618 and IN203621 to I-H-L).