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Leukemia & Lymphoma Volume 48, 2007 - Issue 3
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Original

Wilms' tumor gene (WT1) is predominantly expressed in clonal hematopoietic cells in myelodysplastic syndromes

Dr Xiao Li Department of Hematology, The Sixth People's Hospital affiliated to Shanghai Jiaotong University, Shanghai, ChinaCorrespondence[email protected]
,
Lingyun Wu Department of Hematology, The Sixth People's Hospital affiliated to Shanghai Jiaotong University, Shanghai, China
,
Shaoxu Ying Department of Hematology, The Sixth People's Hospital affiliated to Shanghai Jiaotong University, Shanghai, China
,
Chunkang Chang Department of Hematology, The Sixth People's Hospital affiliated to Shanghai Jiaotong University, Shanghai, China
&
Quan Pu Department of Hematology, The Sixth People's Hospital affiliated to Shanghai Jiaotong University, Shanghai, China
Pages 601-604 | Received 16 Sep 2006, Accepted 07 Nov 2006, Published online: 01 Jul 2009
 
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Abstract

To determine the expression of Wilms' tumor gene (WT1) in clonal hematopoietic cells in patients with myelodysplastic syndromes (MDS), immunochemistry labelling (alkaline phosphatase anti-alkaline phosphatase) and fluorescence in situ hybridization (FISH) were coperformed on bone marrow cytospins from 18 patients whose abnormal karyotypes had been determined by G-binding analysis. Compared to 12 healthy donors, WT1 positive nucleated cells in MDS marrows were significantly higher (t = 2.30; P = 0.032). Moreover, WT1 was expressed predominantly in MDS clonal cells (with abnormal FISH signals) rather than in non-clonal cells (residual normal cells) (t = 2.19; P = 0.043).

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