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Leukemia & Lymphoma Volume 49, 2008 - Issue 1
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Original Article: Clinical

The expression of anamorsin in diffuse large B cell lymphoma: Possible prognostic biomarker for low IPI patients

Takae Shizusawa Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
,
Hirohiko Shibayama Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, JapanCorrespondence[email protected]
,
Shinsuke Murata Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
,
Yuri Saitoh Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
,
Yuna Sugimoto Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
,
Itaru Matsumura Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
,
Hiroyasu Ogawa Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
,
Haruo Sugiyama Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Osaka, Japan
,
Shirou Fukuhara 1st Department of Internal Medicine, Kansai Medical University, Osaka, Japan
,
Masayuki Hino Department of Clinical Hematology and Clinical Diagnostics, Osaka City University, Osaka, Japan
,
Akihisa Kanamaru Department of Hematology, Kinki University School of Medicine, Osaka, Japan
,
Amane Yamauchi Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan
,
Katsuyuki Aozasa Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan
&
Yuzuru Kanakura Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
 show all
Pages 113-121 | Received 26 Jun 2007, Accepted 26 Sep 2007, Published online: 01 Jul 2009
 
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Abstract

Anamorsin is a cell-death-defying factor, which was originally isolated as a molecule that conferred resistance to apoptosis induced by growth factor starvation. In order to evaluate anamorsin expression levels in malignant lymphoma, we immunostained paraffin-embedded sections with anti-anamorsin monoclonal antibodies. About 40% (89/234) of sections from patients with diffuse large B cell lymphoma (DLBCL) showed strong anamorsin expression. Comparing the level of anamorsin expression in DLBCL patients with their clinical features (i.e., overall survival rate, International Prognostic Index (IPI) parameters, and treatment response) revealed no significant correlation between anamorsin expression levels and these clinical features. However, anamorsin expression in DLBCL patients with a low IPI was shown to be an unfavorable biomarker, especially in the patients who received chemotherapy without rituximab. It is suggested that anamorsin might play some roles in the abnormal growth of DLBCL.

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