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Leukemia & Lymphoma Volume 49, 2008 - Issue 4
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Focused Reviews in CML

Immunotherapeutic approaches in chronic myelogenous leukemia

François Guilhot Department of Oncology-Haematology and Cell Therapy, EA 3805 and Clinical Research Centre, CHU de Poitiers, Poitiers, FranceCorrespondence[email protected]
,
Lydia Roy Department of Oncology-Haematology and Cell Therapy, EA 3805 and Clinical Research Centre, CHU de Poitiers, Poitiers, France
,
Pierre-Jean Saulnier Department of Oncology-Haematology and Cell Therapy, EA 3805 and Clinical Research Centre, CHU de Poitiers, Poitiers, France
,
Joëlle Guilhot Department of Oncology-Haematology and Cell Therapy, EA 3805 and Clinical Research Centre, CHU de Poitiers, Poitiers, France
,
Anne Barra Department of Oncology-Haematology and Cell Therapy, EA 3805 and Clinical Research Centre, CHU de Poitiers, Poitiers, France
,
Jean-Marc Gombert Department of Oncology-Haematology and Cell Therapy, EA 3805 and Clinical Research Centre, CHU de Poitiers, Poitiers, France
&
Ali Turhan Department of Oncology-Haematology and Cell Therapy, EA 3805 and Clinical Research Centre, CHU de Poitiers, Poitiers, France
 show all
Pages 629-634 | Published online: 01 Jul 2009
 
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Abstract

Chronic myeloid leukemia (CML) is a stem cell disease in which BCR/ABL plays an important role as oncoprotein and also as a molecular and immunogenic target. In fact, several molecular targeted drugs and immunotherapies have been developed for this disease. In the current article, several immunotherapeutic approaches in CML, including interferon-α and vaccination, are discussed along with results from clinical trials and the value of such immunotherapies in the imatinib-era.

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